Background: Diastolic dysfunction has been described as an early sign of diabetic heart muscle disease preceding the systolic damage. The pathogenesis of ventricular dysfunction remains unknown and has been somewhat controversial. So far, very few population-based studies have been carried out in India, to demonstrate the prevalence of diastolic dysfunction in diabetic subjects. Hence the present study was done at our tertiary care centre to detect left diastolic dysfunction in asymptomatic type 2 diabetes individuals and to use echo-cardiologic assessment as an early detector of left diastolic dysfunction. The aim of this study was to detect left diastolic dysfunction in asymptomatic type 2 diabetes individuals and to use echocardiologic assessment as an early detector of left diastolic dysfunction.Methods: A hospital based cross-sectional observational study was conducted with 50 patients for echocardiographic evaluation of diastolic dysfunction in asymptomatic Type 2 Diabetes Mellitus. E/A <1 and increase in LA size was considered as the evidence of left ventricular Diastolic Dysfunction.Results: 15 (30%) patients were detected with Left Ventricular Diastolic Dysfunction (LVDD) among the 50 patients under study.Conclusions: Diastolic dysfunction in patients with diabetes is present in 30% of patients even when diabetes is present at a younger age, and is of a shorter duration. This dysfunction is suggestive of pre-clinical diabetic cardiomyopathy. E/A, DT and peak A velocity are sensitive indices of diastolic LV dysfunction. Thus, diastolic dysfunction can be used as an early indicator, as it is a precursor to increased LV hypertrophy and clinical left ventricular dysfunction.

Non‐sticking droplets wrapped with fine hydrophobic particles, namely liquid marbles, can be transported both on solid and water pool without an undesired spill of the inner encapsulated liquid. While the stimuli‐responsive release of the inner liquid in the target area is proposed, the time‐programmed release is not yet achieved. Herein, the hydrophobicity of nanoclay is modulated via a catalyst‐free 1,4‐conjugate addition reaction to form liquid marbles. This nanoclay liquid marble is robust and stable in air but collapses on the liquid pool with a specific lifetime. The lifetime of the liquid marble can be modulated over seconds to hours scale depending on the selection of chemically modulated wettability of the nanoclay. The critical mechanism of lifetime modulation is responsible for controlling the coalescence kinetics between the water pool and inner liquid by nanoclays’ high diffusion length and chemically varied water spreading potential. The NC liquid marble's programmable lifetime to ‘time‐bomb’ type drug release and cascade chemical reaction is applied—without requiring any external intervention.

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