BACKGROUND Total Knee Arthroplasty (TKA) has become a standard operative procedure to relieve pain, and to restore alignment and function of patients with advanced arthritis of knees. 1,2,3 Total knee arthroplasty has evolved into a very reliable surgical treatment for advanced arthritis of knee. TKA provides pain relief and improves function for patients with advanced osteoarthritis of the knee. The aim of this study is to prospectively evaluate the clinical and functional outcomes of total knee arthroplasty in arthritic knees in terms of pain relief, range of motion and stability. METHODS We prospectively reviewed a series of 65 primary Total Knee Arthroplasties performed in 40 patients at our institute from November 2014 to November 2017. Of these patients, 12 underwent bilateral TKA in the same sitting, 13 underwent staged bilateral TKA and 15 patients underwent TKA on one side. Patients were followed up to 3 years post-operatively with an average follow up of 24 months and were evaluated with Knee Society Clinical Ratings and radiographic analysis. RESULTS Pre-operative mean of clinical score (pain, ROM and stability) and functional score (walking distance and stair climbing) of patients improved from 48.33 to 92.82 and 49.65 to 88.43 respectively. CONCLUSIONS In this short-term analysis of this prospective observational study, satisfactory results were obtained in a good percentage of arthritic knee patients.