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was estimated taking as a dependent variable the formation of inhibitors in a sample of 112 patients. Results: 85.71% (96) of the patients suffer from type A hemophilia. Regarding the severity of the disease, the distribution of the patients included in the study was 15 mild (13.39%), 17 moderate (15.18 %) and 80 severe (71.43%). 29.46% (33) of the patients have arthropathies. Regarding the determinants, the dose, the number of applications per week, the black race and the increase in the days of initiation of treatment in relation to the diagnosis maintain a direct relationship with the formation of inhibitors. The age measured in years becomes a protective factor, finally the presence of arthropathies and the type of hemophilia were variables that showed no statistically significant relationship in the formation of inhibitors Conclusions: The formation of inhibitors is highly dose-related, the number of weekly applications, being black increases the probability of forming inhibitors. The strategy of reducing the number of days between diagnosis and the start of treatment would play a fundamental role in the appearance of inhibitors. Finally, the evidence shows that the appearance of inhibitors in adults is lower than in infants.