A new TEMPO-catalyzed
aminophosphinoylation of ethers with amines
and H-phosphine oxides was developed for the synthesis of α-aminophosphine
oxides. This metal-free aminophosphinoylation reaction could be conducted
under mild conditions through tandem C(sp3)–H and
C(sp3)–O bond cleavage. The present method offers
a facile and efficient approach to broad range of α-aminophosphine
oxide derivatives in moderate to good yields with excellent functional
group tolerance.
We report a mild method for the synthesis of 4aH-carbazole intermediates with significant synthetic flexibility and variability, and demonstrate the controllable rearrangements of such intermediates to carbazoles. The work further...
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