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The task of predicting the interactions between drugs and targets plays a key role in the process of drug discovery. There is a need to develop novel and efficient prediction approaches in order to avoid costly and laborious yet not-always-deterministic experiments to determine drug–target interactions (DTIs) by experiments alone. These approaches should be capable of identifying the potential DTIs in a timely manner. In this article, we describe the data required for the task of DTI prediction followed by a comprehensive catalog consisting of machine learning methods and databases, which have been proposed and utilized to predict DTIs. The advantages and disadvantages of each set of methods are also briefly discussed. Lastly, the challenges one may face in prediction of DTI using machine learning approaches are highlighted and we conclude by shedding some lights on important future research directions.

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The video-based facial expression recognition aims to classify a given video into several basic emotions. How to integrate facial features of individual frames is crucial for this task. In this paper, we propose the Frame Attention Networks (FAN) 1 , to automatically highlight some discriminative frames in an end-to-end framework. The network takes a video with a variable number of face images as its input and produces a fixed-dimension representation. The whole network is composed of two modules. The feature embedding module is a deep Convolutional Neural Network (CNN) which embeds face images into feature vectors. The frame attention module learns multiple attention weights which are used to adaptively aggregate the feature vectors to form a single discriminative video representation. We conduct extensive experiments on CK+ and AFEW8.0 datasets. Our proposed FAN shows superior performance compared to other CNN based methods and achieves state-of-the-art performance on CK+.