Background: DJ-1 is a protein in association with Parkinson disease and tumorigenesis. Results: DJ-1 increases its mitochondrial distribution in response to ultraviolet B (UVB) irradiation and binds to Bcl-XL in an oxidation-dependent manner to prevent Bcl-XL degradation. Conclusion: Bcl-XL is a new partner of DJ-1 in mitochondria and DJ-1 stabilizes Bcl-XL in response to UVB irradiation. Significance: DJ-1 plays important roles in mitochondria by regulating Bcl-XL functions.
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