From last two to three decades, the world is facing the threat of finding treatment for Cancer. This disease is striking almost ten million people every year throughout the world. Anticancer drugs are those which are used to cure malignant disease i.e. Cancer. These anticancer drugs are available in different forms including alkalyting agents, hormones and anti metabolites. Various examinations reveals that, there will be a adjacent relationship between the characteristics of alkanes and the anticancer drugs viz. Boiling point, melting point, enthalpy etc. with their chemical structures. In this proposed work, various topological indices are defined on some anticancer drugs to help the researchers to know the physical characteristics and chemical reaction associated with them. We also discuss the QSPR analysis of thirteen degree based topological indices. Further, we showcase that the characteristics have good correlation with physico-chemical characteristics of anticancer drugs.
Topological descriptors play a significant role in the selection of leading molecules for studies/drug design/research. As these descriptors equip the quantitative structureactivity relationship (QSAR) models with the physical and chemical properties of the compound, they have become alternative for traditional methods of screening the chemical libraries which is expensive and time consuming. The practicality of these descriptors in QSAR models have been largely demonstrated in the studies by various researchers globally. This study focuses on the chemical compound, carbon nanocone, for which nine degree based topological coindices are determined for), Forgotten coindex (F), Atom bond connectivity coindex (ABC), Geometric arithmetic coindex (GA), Sombor coindex (SO), SS coindex (SS). Accordingly, the structure of the nanocone is considered for k ¼ 4, 5, 6, and 7 for which numerical comparison is tabulated with respect to the graphs to understand the behavior of the coindices.
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