Nowadays, there is an increasing concern for the public health about the consequences from the long and increased use of antibiotics in livestock production. The use of antibiotics in animal feed as growth promoters has been completely banned by the European Union since 2006, based on their possible negative effects on human and animal health. The removal of growth promoters has led to animal performance problems and a rise in the incidence of certain animal diseases. Thus, there is an urgent need to find alternatives to antibiotics, especially in EU. Due to the modern consumers' concern about the potential development of antibiotic-resistant bacteria as well as at the same time the need to prevent economic losses of the farmers, alternatives to antibiotics has been developed to prevent the health problems and to improve the growth performance in farm animals. Owing to the full ban of antibiotic use in EU there is an urgent need to find alternatives to in-feed antibiotics. New strategies and commercial products must be developed to improve animal health and performance, based on their safety, efficacy and cost-effectiveness. The aim of this study is to summarize the beneficial effects of currently used alternatives to in-feed antibiotics, i.e. probiotics, prebiotics, organic acids, phytogenic compounds and zeolites on health and growth performance in farm animals (swine, poultry and ruminants).
Infectious bronchitis (IB), caused by infectious bronchitis virus (IBV), account for severe economic losses in the poultry industry. The continuous emergence of a multitude of IBV variants poses many challenges for its diagnosis and control, and live attenuated vaccines, despite their routine use, still plays a significant role in driving IBV evolution, further complicating the epidemiological scenario. Unfortunately, the impact of different vaccination strategies on IB control, epidemiology, and diagnosis has rarely been investigated.This work presents the results of a large-scale diagnostic survey performed in Poland to study IBV molecular epidemiology and how vaccination may affect the viral circulation in the field. To this purpose, 589 samples were collected between May 2017 and January 2019, tested by reverse transcription-PCR for IBV and sequenced. Vaccine and field strains were discriminated based on genetic and anamnestic information.The most commonly detected lineages were 793B (79%) and variant 2 (17.4%), with sporadic detections of QX, Mass, and D274-like strains. Most of the detected strains had a vaccine origin: 46.3% matched one of the applied vaccines, while 36.5% were genetically related to vaccines not implemented in the respective protocol. Besides their practical value for the proper planning of vaccination protocols in Poland, these results suggest that only a fraction (17.2%) of the circulating strains are field ones, imposing a careful assessment of the actual IBV field menaces. Moreover, phenomena like vaccine spreading and persistence seem to occur commonly, stressing the need to further study the epidemiological consequences of the extensive use of live vaccines.
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