The conversion of a variety of well‐known test reactions, representing the key reactivity patterns of gold catalysis, were analyzed by GC and 1H NMR. The study is focused on establishing of a strategical approach for the consideration of ligand influence and counter anion influence during the catalyst optimization including an industrial perspective. The study shows a dominance of the counter anion, a dominance which up to now has been neglected in most of the routine screenings. In addition, a drastic substrate‐dependency became obvious, even a marginal variation of the substrate already could strongly effect the catalytic activity and change the optimal counter anion or ligand. Based on the collected data a strategic concept for an efficient screening for a specific substrate is introduced, this concept can serve as an important guideline for catalyst optimization in homogeneous gold catalysis.magnified image
A comparison of versatile counter anions was investigated by means of a variety of well‐known test reactions representing the key reactivity patterns of homogeneous gold catalysis, the catalytic activity was monitored by GC and 1H NMR. As previously reported, the counter anion influence is usually more pronounced than the corresponding ligand effect. Due to this, the study is focused on the investigation of counter anions so far not included from investigation of homogeneous gold‐catalyzed reactions. The examinations using so far neglected counter anions (BArF4)−, [B(C6F5)4]−, [Al(OC(CF3)3)4]− and [B(C6F5)3(OAcF)]− showed surpassing or at least similar catalytic activities as the commonly used counter anions. The expanded use of counter anions can occupy an important role in future concerning catalyst optimization in gold catalysis.magnified image
We have probed for
reaction intermediates involved in the dual-gold-catalyzed
activation of a conjugated 1,5-diyne substrate and its further coupling
to benzene in the liquid phase. This was done by sampling the reaction
mixture by electrospray ionization followed by high-resolution ion
mobility mass spectrometryunder conditions allowing for the
resolution of structural isomers differing in their collision cross
sections by less than 0.5%. For the cationic mass corresponding to
catalyst + diyne (activation stage) we resolve four isomers. At the
mass corresponding to catalyst + diyne + benzene, two isomers are
observed. By comparing the experimentally obtained cross sections
to those inferred for model structures derived from density functional
computations, we find our measurements to be consistent with the proposed
solution mechanism. This constitutes the first direct observation
of intermediates in dual gold catalysis and supports the previous
inference that the mechanism involves cooperative interactions between
two gold centers.
The gold‐catalyzed facile synthesis of U‐shaped and S‐shaped bispentalenes is described from easily available tetra(arylethynyl)‐benzenes and ‐naphthalenes. The optoelectronic and transistor properties were also investigated. The selectivity between the U‐shaped and S‐shaped bispentalene isomers can be tuned by the bulkiness of the ligand and the substrates. The S‐shaped naphthalene‐based bispentalene shows a one‐dimensional face‐to‐face packing pattern in solid state and a good hole mobility, indicating that the S‐shaped bispentalene core is highly suitable for transistor applications. The gold‐catalyzed annulation of tetraynes provides a useful protocol in the synthesis of bispentalenes for organic semiconductors.
The reaction of a platinum acetylide derived from a 1,2‐dialkynylarene with a phosphanegold(I) species delivered a σ‐platinum‐π‐gold coordination to the same triple bond of the organic substrate. Cyclopentadienyl‐di(phosphanyl)ruthenium(II) acetylides of the same substrate type gave vinylgold(I)‐vinylideneruthenium(II) complexes in similar reactions. A switch to the corresponding cyclopentadienyl‐di(carbonyl)ruthenium(II) species with a phenyl group on the second alkyne provided vinylruthenium(II) complexes in which the ruthenium was still bound to the same carbon as in the starting material, with a tert‐butyl group on the second alkyne vinylruthenium(II) complexes in which the ruthenium has migrated to another carbon, were obtained. This reactivity mimics the initial steps suggested for dual gold catalysis with these substrates and thus for the first time experimentally confirms the organometallic reactivity patterns proposed for the single steps.magnified image
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