An efficient approach for the synthesis of Nsubstituted indenoisoquinolinones via rhodium(III)-catalyzed C− H bond activation/subsequent [4 + 2] cyclization starting from easily available 2-phenyloxazolines and 2-diazo-1,3-indandiones has been developed. A series of indeno[1,2-c]isoquinolinones were obtained in up to 93% yield through C−H functionalization, followed by intramolecular annulation, elimination, and ringopening in a "one pot manner" under mild reaction conditions. This protocol features excellent atom-and step-economy and provides a novel strategy for the synthesis of N-substituted indenoisoquinolinones and a chance to study their biological activities.

A highly efficient strategy to construct benzo [d][1,3]diazepines via selective CÀ H bond activation of N-aryl amidines and coupling with alkynyl cyclobutyl acetates was achieved successfully by Ru II -catalyzed [5 + 2] cyclization. This protocol features excellent regioselectivity, wide substrate tolerance, mild reaction conditions, which might be potentially applied in the discovery of lead compounds for the developing new drugs.

A mild and efficient tool to construct structurally diverse N/O spiroheterocyclics via Rh(III)-catalyzed [3 + 3] cascade spiroannulation of benzoxazines with 1-diazonaphthalen-2(1H)-ones has been developed. The desired spirooxazine-pyrans could be...

A convenient method for the alkylation of 3-arylbenzo[d]isoxazoles with maleimides under the redox neutral conditions has been developed, giving a series of substituted succinimides in up to 99% yield. This...