Therapeutic study (Systematic review of Level I studies with inconsistent results), Level II.

Background Adults in intensive care units (ICUs) o en su er from a lack of sleep or frequent sleep disruptions. Non-pharmacological interventions can improve the duration and quality of sleep and decrease the risk of sleep disturbance, delirium, post-traumatic stress disorder (PTSD), and the length of stay in the ICU. However, there is no clear evidence of the e ectiveness and harms of di erent non-pharmacological interventions for sleep promotion in adults admitted to the ICU. Objectives To assess the e icacy of non-pharmacological interventions for sleep promotion in critically ill adults in the ICU. To establish whether non-pharmacological interventions are safe and clinically e ective in improving sleep quality and reducing length of ICU stay in critically ill adults. To establish whether non-pharmacological interventions are cost e ective.

No abstract

A new C(2)-symmetric chiral bis-sulfoxide ligand, (R,R)-1,2-bis(tert-butylsulfinyl)benzene, has been designed and prepared by the reaction of (R)-benzyl tert-butylsulfoxide with (R)-thiosulfinate. This ligand exhibits excellent enantioselectivities in the Rh-catalyzed asymmetric 1,4-addition reaction. In particular, the present work has realized access to optically pure flavanones for the first time through 1,4-addition of arylboronic reagents to chromenones.