High-throughput (HT) techniques built upon laboratory automation technology and coupled to statistical experimental design and parallel experimentation have enabled the acceleration of chemical process development across multiple industries. HT technologies are often applied to interrogate wide, often multidimensional experimental spaces to inform the design and optimization of any number of unit operations that chemical engineers use in process development. In this review, we outline the evolution of HT technology and provide a comprehensive overview of how HT automation is used throughout different industries, with a particular focus on chemical and pharmaceutical process development. In addition, we highlight the common strategies of how HT automation is incorporated into routine development activities to maximize its impact in various academic and industrial settings.

Abstract-This paper presents the design and development of a three-phase 10-kV/400-V 500-kVA electronic power transformer (EPT). The power circuit is designed in a modular fashion, i.e., the main circuit consists of many identical ac-dc-dc-ac modules (abbreviated as power modules). Each power module consists of a high-voltage power cell (HVPC), a low-voltage power cell (LVPC), a medium-frequency isolation transformer (MFIT), and a filter. The corresponding control and protection system is developed. A special three-stage start-up strategy is designed to shorten the start-up time and reduce the start-up inrush current. The negative-sequence current compensation is introduced in the input stage to handle the unbalanced loads. To keep the dc-link voltages balanced, an individual dc voltage balancing controller based on regulating the output power of each parallel LVPC is proposed. The detailed control hardware design and software implementation are discussed. The functions of this 10-kV EPT prototype are verified through the laboratory and field tests. The results are shown in the paper. Currently, the prototype is operating in the industrial power grid. Index Terms-Distributionsystem, electronic power transformer (EPT), smart grid, solid state transformer (SST), Industrial prototype Dan Wang (M'07) received the B.S., M.S. and Ph. D. degrees from the in 2010, where he is currently working toward the Ph.D. degree. His research interest is the application of power electronic technology in power systems. Chengxiong Mao (M'93-SM'08) received the B.S., M.S. and Ph.D. degrees from the with the support of Humboldt Foundation. He is currently a Professor with HUST. His fields of interest are power system operation and control, the excitation control of synchronous generator and applications of high power electronic technology to power system. Jiming Lu received the B.S. degree from the In 1984, he joined the faculty of HUST. He is currently a professor with the Department of Electrical Engineering, HUST. His research is focused on the excitation control based on microcomputer. Yuping Duan received the B.S. degree from the He is currently a Senior Engineer with Wuhan Iron and Steel (Group) Corporation (WISCO), Wuhan, China, and he engages in the operation and management of the distribution network. His research is focused on grid operation and reactive power optimization. Jun Qiu received the M.S. degree from Wuhan University of Hydraulic and Electrical Engineering, Wuhan, China, in 1992.He is currently a Senior Engineer with Wuhan Iron and Steel (Group) Corporation (WISCO), Wuhan, China, and his research interests include the grid operation and the safety management of the electrical system. Huihong Cai received the M.S. degree from the and his research interests include the grid operation and reactive power optimization.

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We describe general organic solvent solubility correlations derived from methodology that analyzed 63 240 pieces of automation-enabled solubility data of pharmaceutically relevant compounds and synthetic intermediates. A total of 1125 solubility screening panels were empirically collected on 905 distinct solutes using an Unchained Laboratories (formerly Symyx and Freeslate) automated solubility workflow over the last 15 years. Mining and analyzing these results revealed statistically significant solubility correlations between many solvent pairs and hierarchical clustering of most common organic solvents. This has enabled more efficient experimental solubility surveys by reducing the number of solvents in the experimental design, resulting in savings of both material and throughput.

The development of a safe, robust process for the preparation of ravuconazole (1), an antifungal agent, is described. The discovery and development of procedures enabling the efficient synthesis of multikilogram quantities of 1 and the process demonstration through plant scale preparations are presented. A controlled means to prepare a Grignard reagent and utilization of Fourier Transform Infrared spectroscopy (FTIR) monitoring to safely conduct the reaction is featured.