Julie Tseng-Crank scite author profile

A full-length K+ channel cDNA (RHKI) was isolated from a rat cardiac library using the polymerasc chain reaction (PCR) method and degenerate oligonucleotide primers derived from K" channel sequences conserved between Drosophila Shaker H4 and mouse brain MBKl. Although RHKl was isolated from heart, its expression was found in both heart and brain. The RHKl-encoded protein, when expressed in Xenopus oocytes, gated a 4aminopyridine (4-AP)-sensitive transient outward current. This current is similar to the transient outward current measured in rat ventricular myocytes with respect to voltage-dependence of activation and inactivation, time course of activation and inactivation, and pharmacology.

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Julie Tseng-Crank

Cloning, expression, and distribution of functionally distinct Ca2+-activated K+ channel isoforms from human brain

Multiple products of the drosophila Shaker gene may contribute to potassium channel diversity

Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain.

Molecular cloning and functional expression of a potassium channel cDNA isolated from a rat cardiac library

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