The action of proteases can be controlled by several mechanisms, including regulation through gene expression; post-translational modifications, such as glycosylation; zymogen activation; targeting specific compartments, such as lysosomes and mitochondria; and blocking proteolysis using endogenous inhibitors. Protease inhibitors are important molecules to be explored for the control of proteolytic processes in organisms because of their ability to act on several proteases. In this context, plants synthesize numerous proteins that contribute to protection against attacks by microorganisms (fungi and bacteria) and/or invertebrates (insects and nematodes) through the inhibition of proteases in these organisms. These proteins are widely distributed in the plant kingdom, and are present in higher concentrations in legume seeds (compared to other organs and other botanical families), motivating studies on their inhibitory effects in various organisms, including humans. In most cases, the biological roles of these proteins have been assigned based mostly on their in vitro action, as is the case with enzyme inhibitors. This review highlights the structural evolution, function, and wide variety of effects of plant Kunitz protease inhibitors, and their potential for pharmaceutical application based on their interactions with different proteases.
Tendo em vista a importância da administração do capital de giro e sua relação com o desempenho, somada ao período de recuperação da crise econômica de 2008, este trabalho busca examinar o efeito da gestão do capital de giro na rentabilidade de empresas abertas brasileiras, latino-americanas, e norte-americanas durante um período decisivo em que as organizações tentam se restabelecer no mercado após os anos de recessão econômica. Foi elaborada uma pesquisa descritiva baseada em modelos de regressão linear múltipla com dados em painel fundamentados na literatura sobre o tema. Os resultados indicaram uma relação negativa entre as contas do capital de giro e a rentabilidade das empresas norte-americanas e brasileiras. Os resultados referentes às empresas dos demais países da América Latina não apresentaram significância estatística. Sugere-se para estudos futuros a utilização de outras medidas de desempenho além da utilizada neste trabalho e considerar variáveis macroeconômicas para verificar os impactos da crise em maior profundidade.
Este artigo pode ser copiado, distribuído, exibido, transmitido ou adaptado desde que citados, de forma clara e explícita, o nome da revista, a edição, o ano e as páginas nas quais o artigo foi publicado originalmente, mas sem sugerir que a RAM endosse a reutilização do artigo. Esse termo de licenciamento deve ser explicitado para os casos de reutilização ou distribuição para terceiros. Não é permitido o uso para fins comerciais. This study aimed to analyze determinants related with the delisting of Brazilian companies, through the analysis of the problems of agencies coming from structures of property/control and the internationalization of organizations. Originality/value: The present work seeks to fill the existing gap of more detailed studies related to the delisting of companies in the Brazilian capital market. In addition, it presents a contribution to the literature through the analysis of the relationship between Corporate Governance, Corporate Internationalization and Deslisting from the perspective of Agency Theory. Design/methodological/approach: Four econometric models based on existing literature were elaborated and then analysis of logit regressions with panel data. For data of all organizations listed in BM&FBOVESPA in the period between 2006 and 2015, period in which it was found that 205 businesses closed down their capital. Findings: As a result, it was observed that when considering the year before the delisting, organizations which have greater concentration of property had higher probability of closing their capital, which does not occur when analyzing the control structures. As to the entrance mode into international market, it was noted that there is a negative relationship between entrance mode non-patrimonial and volunteer delisting.v18n4p164-189. Submission: December 30, 2016. Acceptance: March 24, 2017. Evaluation system: double blind review. Universidade Presbiteriana Mackenzie (UPM). Silvio Popadiuk (Editor-in-chief), Silvio Popadiuk (Associate Editor), p. 164-189.
Fixed income funds have the highest proportion of investments in Brazil. Nevertheless, researchers dedicate more attention to equity funds in comparison with fixed income investment funds. The purpose of this study is to evaluate the profitability of the fixed income funds through the application of the unit root test, in order to identify if there are patterns of behavior in such funds that make the data non-stationary. Through descriptive statistics and multivariate regression analysis, we observed certain patterns in the behavior of funds' profitability, which were: lower profitability on Mondays and higher on Tuesdays; Negative relationship between profitability and SELIC rate; and difference in profitability among funds categories. The two unit root tests performed showed that the series was stationary. Nevertheless, by controlling the behavior patterns, an improvement in these statistics was obtained.
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