after nephrectomy was 40 and 70%, respectively, in obese pa-Influence of obesity on the appearance of proteinuria and renal tients at nephrectomy. At 20 years after nephrectomy, these insufficiency after unilateral nephrectomy. percentages were 8 and 35%, respectively. In contrast, in non-Background. Some patients develop proteinuria and proobese patients, the probability of negative proteinuria and norgressive renal failure after unilateral nephrectomy, although mal renal function was 93 and 98%, respectively, at 10 years the majority of patients maintain normal renal function. Rea-(P Ͻ 0.001) and 77 and 91%, respectively, at 20 years (P Ͻ sons to explain this different evolution are not known. 0.001). Multiple logistic regression analysis showed that the Methods. A cross-sectional study was performed in 73 parisk of developing renal disease was only statistically correlated tients who had undergone unilateral nephrectomy 13.6 Ϯ 8.6 with BMI at the time of unilateral nephrectomy (odds ratio years before. Patients with morphologic abnormalities in the 1.34, 1.03 to 1.76 CI). remaining kidney, systemic disorders, or abnormal renal func-Conclusions. Obese patients are at risk for developing protion at the time of nephrectomy were excluded. All of the 73 teinuria and chronic renal failure after unilateral nephrectomy. included patients showed normal renal function and negative Regular and long-term follow-up are recommended in these proteinuria at nephrectomy. The patient's medical records patients. were reviewed, and clinical and analytical data throughout follow-up were obtained. Results. Fifty-three out of the 73 patients (group I) showed a normal renal function and negative proteinuria at the cross-Laboratory studies in animals have shown that a sectional study. The remaining 20 patients (group II) showed marked reduction in renal mass leads to structural and proteinuria (3.4 Ϯ 3.1 g/day). The time elapsed between nephrectomy and proteinuria appearance was 10.1 Ϯ 6.1 years. functional changes in the remaining nephrons [1, 2]. Pro-Thirteen patients of group II had developed renal insufficiency gressive sclerosis of glomeruli, clinically expressed by (serum creatinine at the cross-sectional study of 3.9 ϩ 3.2 mg/ proteinuria, hypertension, and azotemia, is the final re-dL) in addition to proteinuria. The time elapsed between prosult of these maladaptive mechanisms [3, 4]. A clinical teinuria appearance and the onset of renal insufficiency was counterpart of this process, known as glomerular hyper-4.1 Ϯ 4.3 years. Renal insufficiency showed a slowly progressive course in most of these patients. There were no significant filtration or hyperfiltration nephropathy, has been redifferences between group I and group II patients in age, genported in humans with extensive renal mass reductions der, renal function, or blood pressure at the time of nephrec-[5, 6]. However, the long-term consequences of the retomy. In contrast, group II patients showed a body mass index moval of one kidney remain controversial. Several stud-(...