Although prior research has examined how early adversity and chronic stress exposure relate to hypothalamic-pituitary-adrenal (HPA) axis responses to acute stress, to date, no studies have examined how stressors occurring over the entire lifespan predict such responses. To address this issue, we recruited 61 healthy young adults and measured their exposure to 55 different types of acute life events and chronic difficulties occurring over the lifespan. In addition, we characterized differences in participants' HPA axis responses to acute stress by measuring their salivary cortisol and DHEA responses to the Trier Social Stress Test for Groups. Greater cumulative stress exposure was associated with a blunted cortisol response, but a heightened DHEA response, to the acute stressor. Moreover, it was participants' exposure to these stressors (i.e., lifetime count), not their perceived severity, which predicted their cortisol and DHEA responses to acute stress. Furthermore, differential effects were observed by stress exposure domain. Notably, only adulthood and marital/partner stressors significantly predicted cortisol responses to acute stress, whereas stress was more uniformly associated with DHEA responses to the acute stressor. These results thus reveal how cumulative stress exposure is associated with HPA axis responsivity to acute stress, while highlighting the fact that different stressors may have substantially different associations with these biological outcomes.

Psychosocial stress influences cognitive abilities such as long-term memory retrieval. However, less is known about the effects of stress on cognitive flexibility, which is mediated by different neurobiological circuits and could thus be regulated by different neuroendocrine pathways. In this study we randomly assigned healthy adults to an acute stress induction or control condition and subsequently assessed participants’ cognitive flexibility using an open-source version of the Wisconsin Card Sort task. Drawing on work in rodents, we hypothesized that stress would have stronger impairing effects on cognitive flexibility in men than women. As predicted, we found that stress impaired cognitive flexibility in men but did not significantly affect women. Our results thus indicate that stress exerts sex-specific effects on cognitive flexibility in humans and add to the growing body of research highlighting the need to consider sex differences in effects of stress.

Exposure to acute stress can impact performance on numerous cognitive abilities, but little is known about how acute stress affects real-world decision-making ability. In the present study, we induced acute stress with a standard laboratory task involving uncontrollable socio-evaluative stress and subsequently assessed decision-making ability using the Adult Decision Making Competence index. In addition, we took baseline and post-test saliva samples from participants to examine associations between decision-making competence and adrenal hormones. Participants in the stress induction group showed enhanced decision-making competence, relative to controls. Further, although both cortisol and dehydroepiandrosterone (DHEA) reactivity predicted decision-making competence when considered in isolation, DHEA was a significantly better predictor than cortisol when both hormones were considered simultaneously. Thus, our results show that exposure to acute stress can have beneficial effects on the cognitive ability underpinning real-world decision-making and that this effect relates to DHEA reactivity more than cortisol.

Individuals with high levels of depressive symptoms find rewards to be less reinforcing and punishment more aversive, which may lead them to avoid risk taking. To examine the relation between risk taking and depressive symptoms, undergraduate participants (N = 138) completed the Balloon Analogue Risk Task (BART), which effectively measures affective risk taking. Participants' goal was to maximize the virtual money earned from the task by completing trials that ended in either a reward (i.e., gain in virtual money) or a punishment (i.e., loss of virtual money and premature end to the trial). Higher (vs. lower) levels of depressive symptoms were associated with more pumps (i.e., greater risk taking) after a reward; higher levels of depressive symptoms were associated with fewer pumps following a punishment than a reward (i.e., greater punishment sensitivity). Greater punishment sensitivity (i.e., lower risk-taking following setbacks) in individuals with higher levels of depressive symptoms may contribute to the maintenance of depressed mood by limiting rewarding experiences that could elevate their mood. The findings should be replicated in a clinical sample.

To minimize distress associated with choices with uncertain consequences, individuals with high levels of anxiety may continue with familiar choices rather than seek out novel choices. As a result, they might be more vulnerable to sunk cost fallacy, the inability to ignore unrecoverable prior investments when making decisions about the future. Considering that cognitive reappraisal may mitigate the association between anxiety and poor decision making, the present study examined the relations between cognitive reappraisal, anxiety, and resistance to sunk cost. To this end, 108 undergraduates completed questionnaires assessing their tendency to engage in cognitive reappraisal, severity of anxiety, and resistance to sunk cost. Participants' tendency to engage in cognitive reappraisal moderated the relation between the severity of anxiety and resistance to sunk cost. However, in individuals who typically engaged in cognitive reappraisal, only lower levels of anxiety were associated with higher resistance to sunk cost. Individuals with high vs. low levels of anxiety might differ in how they reappraise negative situations, which can consequently affect resistance to sunk cost.