Ninety‐eight women with lobular carcinoma in situ (LICS) of the breast were identified over a 16‐year period. Consecutive slide review of all breast material over a 12‐year period identified 25 women with LCIS on biopsy who did not undergo mastectomy. Only 1 woman (4%) in a complete followup averaging 17.5 years developed ipsilateral invasive carcinoma. of 32 women with a contralateral breast at risk, 3 (9.7%) developed infiltrating carcinoma. LCIS was found with infiltrating carcinoma, especially of the lobular (small cell) type, with such frequency as to indicate a close relationship. However, the risk of subsequent development of infiltrating carcinoma in the breast with biopsyproven LCIS is shown to be substantially less than indicated by previous authors. This suggests that careful and prolonged followup may suffice for the woman whose breast biopsy contains lobular carcinoma in situ.

In a study of the relationship between gastric polyps and carcinoma, a series of 97 cases of gastric polyps were studied histologically and follow‐up information obtained. Thirty‐five per cent of the total series of gastric polyps were found as incidental findings in stomachs with gastric carcinoma. Polyps were subdivided by gross appearance into single polyps, multiple discrete polyps, or gastric polyposis; no significant difference in association with carcinoma was found for these gross types. Polyps could be subdivided microscopically into hyperplastic and adenomatous types. Hyperplastic polyps were relatively more common (76%), and were randomly distributed in the stomach. Adenomatous polyps were usually antral in location and were histologically similar to the adenomatous polyps of the colon. Marked epithelial atypia (in‐situ carcinoma) was seen only in polyps of the adenomatous type. Adenomatous polyps were associated with carcinoma more frequently than hyperplastic polyps—59% and 28%, respectively. Follow‐up information on a total of 40 patients who underwent surgery for gastric polyps without associated carcinoma showed that 3 developed subsequent polyps and only one developed a polypoid carcinoma. The initial polyps in these cases were multiple, greater than 2 cm in size, and, in each case, at least one was of the adenomatous type. The subdivision of polyps into 2 histologic types revealed the close morphological and statistical relationship of the adenomatous type of gastric polyp to gastric carcinoma. This relationship is otherwise obscured by the presence of the more numerous hyperplastic polyps. In almost all circumstances, simple polypectomy with a rim of uninvolved adjacent mucosa is sufficient treatment.

The controversy about the treatment of carcinoma of the prostate has increased in the last decade, with most urologists favoring radical prostatectomy rather than primary irradiation. Several reports of persistent tumors in 50% to 90% of patients after external irradiation and permanent iodine‐125 implantation of the prostate have been disturbing. From July 1977 to December 1985, 200 patients with adenocarcinoma of the prostate were treated by combining bilateral pelvic lymphadenectomy and temporary interstitial iridium‐192 implantation of the prostate, followed by external irradiation. Seventy‐four (36%) patients underwent biopsies of the prostate 4 months to 2 years after completion of the irradiation. Only 12 (16%) patients had persistent tumors. Complications were minimized subsequently by dose modifications.

We report a case of malignant melanoma of the renal pelvis presenting as a primary tumor and review the relevant literature.