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Unique-hue spectral loci were measured under conditions of neutral adaptation as part of a study of hue-response recovery following chromatic adaptation. Four observers adjusted the wavelength of the test-field until it appeared to be neither yellow nor blue (unique green) or neither red nor green (unique yellow and blue) in randomized sessions. The results showed that there were marked individual differences and long-term drifts in the unique-hue settings over a period of a month.The variability within a session was minimal.Measurements of unique-hue spectral loci are important in specifying the characteristics of normal color vision and in theorizing about their underlying mechanisms