Dutch Resolution is the term given to the use of mixtures (families) of resolving agents in classical resolutions. In this status report an overview is given of the latest results and new (possible) families of resolving agents are introduced. The concept of families is discussed as well as the factors that come into play on use of families. Practical aspects of Dutch Resolution in particular and resolutions in general are discussed.
Schwarze Schafe in der Familie? Für einen kombinatorischen Prozess zur Racematspaltung über die Trennung diastereomerer Salze mithilfe von Gemischen („Familien“) strukturell verwandter Reagentien (Beispiele sind gezeigt) wurde der Begriff „Dutch Resolution“ geprägt. Einige Familienmitglieder werden nicht in die Salze eingebaut; offensichtlich verhindern sie die Keimbildung. Daraus ergibt sich eine vereinfachte Zwei‐Komponenten‐Methode mit hohen Erfolgsquoten schon zu Beginn des (iterativen) Prozesses.
Citation for published version (APA): Dalmolen, J., Tiemersma-Wegman, TD., Nieuwenhuijzen, JW., van der Sluis, M., van Echten, E., Vries, TR., ... Broxterman, Q. B. (2005). The Dutch resolution variant of the classical resolution of racemates by formation of diastereomeric salts: Family behaviour in nucleation inhibition. Chemistry, 11(19), 5619-5624.
Not double Dutch! The resolution of racemates with families of structurally related resolving agents (see examples depicted) is termed Dutch Resolution. Certain family members are regularly not incorporated; these turn out to be nucleation inhibitors. This leads to a simplified, two‐component resolution procedure with a high chance of initial success.
The synthesis of enantiopure 1-aryl-1-butylamines via a highly diastereoselective addition of allylzinc bromide to imines derived from (R)-phenylglycine amide is reported. These are synthesised by a three-step procedure, which involves: (a) formation of the chiral imines; (b) asymmetric addition of the allylzinc reagent; (c) removal of the chiral auxiliary by
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