Objective: We investigated whether 33 subjects with a typical history of AIA tolerated the new COX-2-selective NSAID celecoxib. Methods: All subjects displayed current aspirin sensitivity in oral or inhalation challenge tests. The subjects first underwent a double-blind, randomized, cross-over, increasing-dose challenge with placebo or celecoxib (10, 30, or 100 mg in suspension) on 2 occasions 7 days apart. Thereafter, all subjects were exposed to 400 mg of celecoxib administered during an open challenge session as two 200-mg doses 2 hours apart. Lung function, clinical symptoms, and urinary excretion of leukotriene E 4 (LTE 4 ) were monitored, with the latter being a sensitive biochemical marker of aspirin intolerance. Results: There were no changes in lung function or extrapulmonary symptoms during the double-blind sessions or in urinary excretion of LTE 4 . Also, the highest recommended daily dose of celecoxib was well tolerated, with no symptoms, lung function changes, or alterations in urinary LTE 4 levels. Conclusions: A group of subjects with clinically well-documented AIA tolerated acute challenge with the selective COX-2 inhibitor celecoxib. The findings indicate that the intolerance reaction in AIA is due to inhibition of COX-1. Large long-term studies of COX-2 inhibitors in AIA should be undertaken. (J Allergy Clin Immunol 2003;111:1116-21.)

15I was pleased to be asked by Shannon Supple and Nina Schneider, co-chairs of the 2012 RBMS preconference, to reflect on the themes of the conference in these pages. The presentations were engrossing and provocative, and I hope here to offer some equally provocative thoughts in response as my contribution to the ongoing discussion about the peril and promise-mostly, I firmly believe, the latter-that the future holds for our profession.The future of special collections is distribution. It hardly needs to be said that digitization, and the ability to share digitized materials widely, is enacting a wholesale transformation on the work of special collections librarianship. It's easy, in the quiet of the reading room, to imagine that special collections is somewhat immune from the challenges facing other areas of the profession; but, even if that were something to be hoped for, it would be a false hope. Special collections will increasingly serve an audience that does not, and in many cases need not, cross its threshold. Changes in our base of users will necessitate changes in our methods of assisting those users, as well as changes in the kinds of materials we acquire and prioritize for conservation and digitization.

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This chapter examines the collaborative knowledge building activities of MST3K fans as they relate to the decoding of jokes and references in the show. We describe the different types of references that make up the show and explore the various internet-based resources that have been constructed by fans in their attempts to decode show’s references, and discuss how these sites work as a form of collective intelligence (Jenkins 2006).

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