Objective. To evaluate the ability of third-and fourth-year pharmacy students to identify clinically significant drug-drug interactions (DDIs) Methods. A questionnaire designed to measure DDI knowledge was disseminated to fourth-year pharmacy students in a school of pharmacy. A second questionnaire was distributed to third-year pharmacy students in 2 schools of pharmacy (schools A and B) and re-administered to students in 1 of the schools 1 year later. Results. Class of 2005 fourth-year pharmacy students correctly categorized an average of 52% 6 13% DDI pairs on the first questionnaire. Third-year pharmacy students at schools A and B correctly categorized an average of 61% 6 18% and 66% 6 15% of DDI pairs, respectively. The average percentage of correct responses for fourth-year students from the class of 2007 was 65% (6 17%). Conclusion. Pharmacy students' ability to identify important DDIs is far from optimal, even after completing experiential requirements.
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