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Our goal was to compare and contrast the correlates of academic- and recreation-motivated misuse of prescription stimulants (MPS). Questionnaires were distributed to a probability sample of students attending two universities. We used a series of logistic regression analyses to examine intrapersonal, interpersonal, and environmental correlates of use among academic-motivated users (versus nonacademic-motivated users) and recreation-motivated users (versus nonrecreation-motivated users; N = 257 students with MPS experience). Sensations seeking, older age, academic concern, family perception of MPS, family and faculty endorsement of MPS, perceived prevalence of MPS among friends, and financial stress were unique correlates of recreation-motivated MPS. Inattention, friends’ perception of MPS, friend endorsement of MPS, perception of willingness of health care providers to write prescriptions and negative expectancies were unique correlates of academic-motivated MPS. Variables that were correlates of both motives were race/ethnicity, year in school, avoidance self-efficacy, diversion, positive MPS expectancies, MPS intention, and other substance use. These findings have important prevention and intervention implications.

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To examine the prevalence, characteristics, and utility of ecological theory in explaining prescription stimulant misuse, a probability sample of 499 students from one southern California university (response rate = 94.71%) completed a 100-item paper-based survey. The illicit use of prescription stimulants (IUPS) during college was reported by approximately 21% of students, with approximately 13% of users reporting 10 or more occurrences per academic term. Characteristics of use that were examined suggest a growing trend toward recreational use. We used structural equation modeling to replicate a previously tested ecological model. The number of significant paths in this replication study (i.e., 22) was similar to the number of significant paths in the original study (i.e., 25), and 21 of the significant paths from the original study retained their significance in the replication. Results confirm prescription stimulant misuse remains prevalent, characteristics of the behavior are cause for concern, and ecological theories are a useful tool for explaining the multifaceted nature of IUPS.