Pseudomonas oleovorans was grown separately on
5-(4‘-tolyl)valeric acid, 5-(4‘-ethylphenyl)valeric acid, 5-(4‘-biphenyl)valeric acid, and
8-(4‘-tolyl)octanoic acid either as the sole carbon source or
as
a coefeed with either nonanoic acid or 5-phenylvaleric acid. For
polymer production, 5-(4‘-tolyl)valeric
acid was the most effective growth substrate of the five. It
resulted in the production of poly-3-hydroxy-5-(4‘-tolyl)valerate, a crystalline polymer with a glass transition
temperature of 18 °C and a melting
transition of 95 °C. This poly(3-hydroxyalkanoate) (PHA) is
apparently the first example of a crystalline
aromatic-containing bacterial PHA. When P.
oleovorans was cofed an equimolar mixture of
5-phenylvaleric
acid and 5-(4‘-tolyl)valeric acid, the polymer produced contained
36 mol % of 3-hydroxy-5-phenylvalerate
and 64 mol % of 3-hydroxy-5-(4‘-tolyl)valerate, and it did not
crystallize.
Prolonged percutaneous blockade of peripheral nerves is feasible. The recovery from blockade is complete, and plasma bupivacaine levels are far below the range associated with systemic toxicity. The mechanisms underlying the dexamethasone block-prolonging effect are under investigation.
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