Systemic erythematosus lupus is a chronic inflammatory disease of autoimmune nature. This illness can affect all organs, but one of the most common illnesses is lupus nephritis. Patients with renal impairment, despite aggressive immunosuppressive medication carry the risk of developing terminal renal disease and doing dialysis or renal transplant. The purpose of this study is to reflect global statistics on the frequency of the development of terminal renal disease in lupus nephritis patients as an awareness-raising way to stimulate studies that present a successful treatment or screening protocol in preventing this complication. This study is a review based on the research of world studies and literature regarding the prevalence of terminal renal disease in lupus nephritis patients. Over 50% of patients with LES, depending on different regions of the world, race / ethnicity develop lupus nephritis. 10-30% of lupus nephritis cases develop terminal renal disease where among the major risk factors are new age, nephrotic proteinuria, disease activity index, histological class of renal impairment, high creatinine, lack of remission, etc. Performing as early as possible the renal transplant increases the lifespan of patients with terminal renal disease. It is very difficult to prevent renal impairment in patients with LES, more so when some of them have lupus nephritis as the initial manifestation. However, since more than 50% of LES patients develop lupus nephritis and 10 to 30% of lupus nephritis cases develop terminal renal disease, studies should be encouraged to determine a successful treatment or screening protocol in preventing this complication.
Vasculitis is an inflammation of the blood vessels. It can affect any blood vessel in the body by manifesting a variety of systemic, non-specific symptoms that make difficult the diagnosis of this pathology and especially its specific form. In front of any patient suspected of being affected by vasculitis, some questions are asked: Is the vasculitis or other pathology that camouflages, whether it is primary or secondary vasculitis, in which vessels this pathology extends, how can the diagnosis be confirmed and how can it be determined the type of vasculitis? The purpose of this study is to inform about the protocols to be followed to perform differential diagnosis of vasculitis types. This study is a review based on the research of world studies and literature regarding the recommendations for performing differential diagnosis among the variety of vasculitis forms. Primary patient assessment involves taking the history of the medications it uses, risk factors for infectious pathology, history of cardiac valve pathologies, and autoimmune pathologies. Then laboratory and imaging studies are carried out, aiming at setting the diagnosis, determining the affected organ and the degree of disease activity. And recently we refer to algorithms to make differential diagnosis between the varieties of vasculitis forms. Despite the diagnostic difficulties of vasculitis, the variety of its forms, the separation of responsibilities among many specialities, there are protocols that need to be followed rigorously to arrive at a safe diagnosis as well as auxiliary algorithms to distinguish the type of vasculitis.
Vasculitis is an inflammation of the blood vessels. It can affect any blood vessel in the body by manifesting a variety of systemic, non-specific symptoms that make difficult the diagnosis of this pathology and especially its specific form. In front of any patient suspected of being affected by vasculitis, some questions are asked: Is the vasculitis or other pathology that camouflages, whether it is primary or secondary vasculitis, in which vessels this pathology extends, how can the diagnosis be confirmed and how can it be determined the type of vasculitis?The purpose of this study is to inform about the protocols to be followed to perform differential diagnosis of vasculitis types.This study is a review based on the research of world studies and literature regarding the recommendations for performing differential diagnosis among the variety of vasculitis forms.Primary patient assessment involves taking the history of the medications it uses, risk factors for infectious pathology, history of cardiac valve pathologies, and autoimmune pathologies. Then laboratory and imaging studies are carried out, aiming at setting the diagnosis, determining the affected organ and the degree of disease activity. And recently we refer to algorithms to make differential diagnosis between the varieties of vasculitis forms.Despite the diagnostic difficulties of vasculitis, the variety of its forms, the separation of responsibilities among many specialities, there are protocols that need to be followed rigorously to arrive at a safe diagnosis as well as auxiliary algorithms to distinguish the type of vasculitis.
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