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Water as a common, easily obtained, and environmentally friendly stimulus has been explored in stimuli-responsive materials. In this paper, a series of composites, named as PVA­(n)-CMC­(m)-GA, were prepared by filling the carboxymethyl cellulose sodium (CMC) into chemical cross-linked poly­(vinyl alcohol) (PVA). These composites demonstrated both water induced shape memory and self-healing effect. CMC with water sensitivity help the composite absorbing water to decrease the T g of composite to cause shape recovery. And CMC with water solubility is also a good healing agent, which can freely move across the cutting cross-section in wet condition and form hydrogen bonds with PVA chains in dry condition to achieve healing. Water can affect the hydrogen bonding interactions between CMC and PVA, and which play a key role in the water-stimuli responsive properties. This study provides a relatively simple and low cost way to obtain water-induced multifunction materials.

Background Intraductal carcinoma of the prostate (IDC-P) is a subtype of prostate cancer featured by poor prognosis. Previous studies suggested IDC-P could have a potentially unstable genome. Homologous recombination deficiency (HRD) score is a result-oriented method to describe the genomic instability status. This study investigates the association of HRD scores with IDC-P and other clinicopathological factors and the prognostic implication of HRD scores in an aggressive prostate cancer cohort. Methods This study involved 123 PCa patients, including high-risk localized (M0) and de novo metastatic (M1) diseases. HRD score is calculated based on over 10,000 single-nucleotide polymorphisms distributed across the human genome. We explored the association between HRD scores and clinicopathological characteristics, genomic alterations, and patients’ prognoses using rank-sum tests, chi-square tests, Kaplan-Meier curves, and Cox proportional hazards method. Results The median HRD score of this cohort is 21.0, with 65 (52.8%) patients showing HRD score≥21. Tumors with IDC-P displayed higher HRD scores than adenocarcinoma (P=0.002); other high HRD score-related factors included M1 (P =0.008) and high ISUP grades (4–5) (P=0.001). MYC mutations were associated with high HRD scores (P<0.001) in the total cohort. TP53 mutations (P=0.010) and HRR pathway mutations (P=0.028) corresponded to high HRD scores in IDC-P positive and non-IDC-P patients, respectively, but not vice versa. HRD scores higher than 21 indicated significantly worse survival in the total cohort. Conclusions M1, high Gleason score, and IDC-P pathology represent higher HRD scores in PCa. Tumors with IDC-P might have different driven mechanisms for high HRD scores than non-IDC-P. HRD score displayed prognostic value in this aggressive prostate cancer cohort.