A series of indole-derived alkenes
have been designed and applied
in a photocatalytic cascade reaction with bromodifluoroacetate esters,
affording an unknown type of tetracyclic tetrahydro-γ-carboline
derivative in up to 90% yields. Mechanistic studies suggest that the
reaction proceeds with tetrahydro-γ-carboline as a key intermediate.
The reaction tolerates a diverse pool of substrates, which provides
an efficient method for the construction of tetracyclic tetrahydro-γ-carboline
compounds.
An electrochemical sulfonylation-triggered
cyclization
reaction
of indole-tethered terminal alkynes with sulfinates as sulfonyl sources
has been developed, which affords exocyclic alkenyl tetrahydrocarbazoles
in good chemical yields. This reaction features convenient operation
and tolerates a wide scope of substrates with a variety of electronically
and sterically diverse substituents. Furthermore, high E-stereoselectivity is observed for this reaction, which provides
an efficient method for the preparation of functionalized tetrahydrocarbazole
derivatives.
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