With mixed transition-metal-complex, alkali-metal, or organic cations as structure-directing agents, a series of novel two-dimensional (2D) layered inorganic-organic hybrid iodoargentates, namely, Kx[TM(2,2-bipy)3]2Ag6I11 (TM = Mn (1), Fe (2), Co (3), Ni (4), Zn (5); x = 0.89-1) and [(Ni(2,2-bipy)3][H-2,2-bipy]Ag3I6 (6), have been solvothermally synthesized and structurally characterized. All the title compounds feature 2D microporous layers composed by [Ag3I7] secondary building units based on AgI4 tetrahedra. Differently, the [Ag3I7] trimers are directly interconnected via corner-sharing to form the 2D [Ag6I11](5-) layer in compounds 1-5, whereas two neighboring [Ag3I7] trimers are initially condensed into a hexameric [Ag6I12] ternary building unit as a new node, which further self-assembles, leading to the 2D [Ag6I10](4-) layer in compound 6. The UV-vis diffuse-reflectance measurements reveal that all the compounds possess proper semiconductor behaviors with tunable band gaps of 1.66-2.75 eV, which lead to highly efficient photocatalytic degradation activities over organic pollutants under visible light irradiation compared to that of N-dotted P25. Interestingly, all the samples feature distinct photodegradative speeds at the same reaction conditions, and compound 1 features the highest photocatalytic activity among the title phases. The luminescence properties, band structures, and thermal stabilities were also studied.
The emergence of drug-resistant bacteria severely challenges the antimicrobial agents and antibacterial strategy. Here, we demonstrate a novel, simple, and highly efficient combination therapy strategy by direct combinations of cationic conjugated polymers (CCPs) with polypeptide antibiotics against Gram-negative and Gram-positive bacteria based on a synergistic antibacterial effect. The combination therapy method enhances the antibacterial efficacy with a significantly reduced antibiotic dosage. Also, the highly efficient and synergistic killing of drug-resistant bacteria is realized. Using combinations of CCPs and antibiotics to show increased antibacterial activity, this strategy will provide a much wider scope of the discovery of efficient antibacterial systems than that of antibiotic-antibiotic combinations. The proposed combination therapy method provides a universal and powerful platform for the treatment of pathogens, in particular, the drug-resistant bacteria, and also opens a new way for the development of efficient antibacterial systems.
By using transitional metal (TM) complex cations as structure-directing agents (SDAs), a series of new hybrid cuprous halides have been solvothermally synthesized and structurally characterized. The title compounds feature abundant architectures ranging from one-dimensional (1D) chains to two-dimensional (2D) layers built from the self-condensation of [CuX4] tetrahedrons and/or [CuX3] triangles. The UV-vis diffuse-reflectance measurements reveal that the title compounds possesses semiconductor behaviors with smaller band gaps of 1.44-1.95 eV, and show highly efficient photocatalytic degradation activities over organic pollutant than N-doped P25 under visible light irradiation. 661x495mm (96 x 96 DPI)
AbstractBy using transitional metal (TM) complex cations as structure-directing agents (SDAs), a series of new hybrid cuprous halides with abundant architectures ranging from one-dimensional (1D) ribbons to two-dimensional (2D) layers have been solvothermally prepared and structurally characterized.Compounds [TM(2,2-bipy) 3 ]Cu 5 I 7 (TM = Fe (1), Co(2) and Ni (3)) feature 1D [Cu 5 I 7 ] 2-chains formed by the interconnection of [Cu 5 I 10 ] units via edge-sharing. In compounds [TM(2,2-bipy) 2 I] 2 Cu 7 I 9 (TM = Mn (4), Cu(5), Ru (6)), the [Cu 5 I 9 ] units and [Cu 2 I 6 ] dimers are alternately interlinked via edge-sharing to form the 1D [Cu 7 I 9 ] 2-chains. Compound [Cu(2,2-bipy) 2 I][(Me) 2 -2,2-bipy]Cu 8 I 11 (7) contains a new 1D [Cu 8 I 11 ] 3-chain composed of complex [Cu 8 I 13 ] units based on CuI 4 tetrahedra and CuI 3 triangles. Compound [Co(2,2-bipy) 3 ]Cu 5 Br 8 (8) features 1D [Cu 5 Br 8 ] 3-anionic chain built form the interconnection of [Cu 6 Br 10 ] units and linear [Cu 4 Br 8 ] tetramers. In compound K[Mn(2,2-bipy) 3 ] 2 Cu 6 I 11 (9), the [Cu 3 I 7 ] secondary building units (SBUs) are directly interconnected to form 2D [Cu 6 I 11 ] 5-layers, which are further interconnected by K + ions via weak K-I bonds to generate a 3D [K@Cu 6 I 11 ] 4-framework with 1D large channels occupied by [Mn(2,2-bipy) 3 ] 2+ complexes. The UV-vis diffusereflectance measurements reveal that the title compounds possess semiconductor behaviors with smaller band gaps of 1.44-1.95 eV, and samples 4, 5 and 9 show highly efficient photocatalytic degradation activities over organic pollutant than N-doped P25 under visible light irradiation.
(S)-2-Chloro-1-(3,4-difluorophenyl)ethanol
(1) is a vital chiral intermediate for the synthesis
of Ticagreloran effective treatment for acute coronary syndromes.
A ketoreductase (KRED) KR-01 in our KRED library was screened to transform
2-chloro-1-(3,4-difluorophenyl)ethanone (2) into the
chiral alcohol 1. During process optimization, the bioreduction
procedure was performed at a substrate concentration of 500 g/L, giving
a near 100% conversion with >99.9% ee. The product 1 was
directly obtained by extraction and can be used for the synthesis
of (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic
acid ethyl ester (3) with a yield of 98% and >99.9%
de,
greatly simplifying the original process operation and reducing the
safety risk. This process is green and environmentally sound with
high productivity of biocatalysis and a space–time yield of
145.8 mmol/L/h. It has an opportunity to be very useful in industrial
applications. Additional studies have indicated that KR-01 can also
be used to prepare (R)-1-(3,5-bis(trifluoromethyl)phenyl)ethanol
(4) with a substrate concentration of 500g/L.
Four new hybrid iodoargentates have been solvothermally prepared and structurally characterized. The title compounds possess semiconductor characterizations and efficient photocatalytic activities under visible light irradiation.
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