Pyoderma gangrenosum (PG) is a chronic, painful ulcerated skin disease of unknown etiology. Its association with inflammatory bowel disease like ulcerative colitis is common. The lesions generally appear during the course of active bowel disease, frequently concur with exacerbations of colitis, sometimes with inactive ulcerative colitis. 15 to 20 % of patients with Pyoderma gangrenosum have ulcerative colitis and 0.5 to 5 % of patients with ulcerative colitis have Pyoderma gangrenosum. occasionally skin lesions may preceed active inflammation of colon. Here we report a case of 50 year old female presenting with large ulcerated lesion over the anterior aspect of the middle 1/3 rd of left leg associated with severe pain and bloody discharge. skin biopsy shows epidermis with necrosis and diffuse dense neutrophilic infiltrate in superficial epidermis extending into the deep dermis. Colonoscopy shows features of ulcerative colitis. Patient showed rapid response with systemic steroids and specific treatment with 5-amino salicylic acid (mesalamine). ulcer healed within 6 weeks and followed for 3months with no recurrence.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.