Prevalence of dysmenorrhea in university students and its relation to school absenteism, physical exercise and use of medicinesPrevalencia de dismenorrea en universitarias y su relación con absentismo escolar, actividad física y uso de medicamentos RESUMO Objetivo: Verificar a prevalência de dismenorreia em universitárias e a frequência de absenteísmo escolar, prática de exercícios físicos e utilização de medicamentos para tratamento dessa síndrome. Métodos: Trata-se de um estudo transversal realizado com jovens universitárias por meio de um questionário autoaplicado contendo dados sociodemográficos, obstétricos e ginecológicos. Avaliou-se a dor menstrual através da escala visual analógica (EVA). Para análise descritiva dos dados, foram utilizadas frequência, percentagem, média e desvio padrão. Resultados: A amostra constou de 130 mulheres, com idade entre 17 e 33 anos (20,6±2,7 anos). Cento e vinte quatro voluntárias (95,4%) queixaram-se de dismenorreia. Quanto à sua intensidade, a maioria sentia dor menstrual moderada ou grave (51,6% e 36,3%, respectivamente). Sessenta (48,4%) participantes referiram absenteísmo escolar devido à dor menstrual; dessas, nenhuma tinha dor leve. Dentre as voluntárias que apresentavam dismenorreia moderada e grave, apenas 24 (20,2%) praticavam exercício físico e a maioria delas (79%) necessitava utilizar fármacos para tratar essa síndrome. Conclusão: A dismenorreia teve alta prevalência entre as universitárias avaliadas e na maior parte dos casos se apresentou com intensidade limitante, levando ao absenteísmo escolar. A maioria das mulheres com dismenorreia de intensidades moderada e grave não pratica exercício físico e necessita utilizar medicamentos para tratar essa síndrome.
The natural alkaloid epiisopiloturine has recently become the focus of study for various medicinal properties, particularly for its anti-inflammatory and antischistosomal effect. The incorporation of active molecules in natural polymeric matrices has garnered increasing interest during recent decades. A new derivative of cashew gum successfully obtained by gum acetylation has shown great potential as a carrier in controlled drug release systems. In this work, epiisopiloturine was encapsulated in acetylated cashew gum nanoparticles in order to increase solubility and allow slow release, whereas the morphology results were supported by computer simulations. The particles were produced under a variety of conditions, and thoroughly characterized using light scattering and microscopic techniques. The particles were spherical and highly stable in solution, and showed drug incorporation at high levels, up to 55% efficiency. Using a dialysis-based in vitro assay, these particles were shown to release the drug via a Fickian diffusion mechanism, leading to gradual drug release over approximately 6 h. These nanoparticles show potential for the use as drug delivery system, while studies on their potential anti-inflammatory action, as well as toxicity and efficacy assays would need to be performed in the future to confirm their suitability as drug delivery candidates.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.