Molecular and electronic structures and optical absorption properties of oligothiophenes used for spectral assignment of amyloid deposits have been investigated for a family of probes known as luminescent conjugated oligothiophenes (LCOs). Theoretical absorption spectra have been determined using conformational averaging, combining classical molecular dynamics (MD) simulations with quantum mechanical/molecular mechanics (QM/MM) time-dependent density functional theory (TD-DFT) spectrum calculations. Theoretical absorption spectra are in excellent agreement with experiments, showing average errors below 5 nm for absorption maxima. To couple observed properties to molecular structures, a measure of planarity is defined, revealing a strong correlation between the transition wavelength of the first and dominating electronically excited state and dihedral rotations. It is shown that from this correlation, predictions can be made of the absorption properties of probes based only on information from MD trajectories. We show experimentally that red shifts observed in the excitation maxima of LCOs when bound to amyloid protein aggregates are also evident in absorption spectra. We predict that these red shifts are due to conformational restriction of the LCO in a protein binding pocket, causing a planarization of the conjugated backbone. On the basis of our studies of planarity, it is shown that such shifts are both possible and realistic.

The full Mueller matrix for a Spectralon white reflectance standard was measured in the incidence plane, to obtain the polarization state of the scattered light for different angles of illumination. The experimental setup was a Mueller matrix ellipsometer, by which measurements were performed for scattering angles measured relative to the normal of the Spectralon surface from -90° to 90° sampled at every 2.5° for an illumination wavelength of 532 nm. Previously, the polarization of light scattered from Spectralon white reflectance standards was measured only for four of the elements of the Muller matrix. As in previous investigations, the reflection properties of the Spectralon white reflectance standard was found to be close to those of a Lambertian surface for small scattering and illumination angles. At large scattering and illumination angles, all elements of the Mueller matrix were found to deviate from those of a Lambertian surface. A simple empirical model with only two parameters, was developed, and used to simulate the measured results with fairly good accuracy.

Selection of operating wavelength of the Yb-doped fiber-ring lasers using long-period fiber gratings (LPFGs) is proposed. In the proposed method, customized LPFG that sustains high powers serves as a broad-band rejection filter. It modifies the net gain profile of the laser, enabling the peak gain to occur at a designed wavelength. Spectral range of oscillation between 1050-1110 nm was experimentally demonstrated. The spectral range can be extended to both shorter and longer wavelengths with proper design of the LPFG and length of the Yb-doped fiber. The gratings were inscribed by CO 2 laser and the grating period down to 175 μm was achieved being, to our best knowledge, the shortest reported LPFG period using this technique. Setup of the fiber laser

International audienceExperimental observation of the self-induced laser line sweeping (SLLS) in fiber ring lasers is presented. The SLLS with the same gain fiber is studied in Fabry-Perot cavity for comparison. The SLLS effect manifests itself as a laser wavelength drift with speed of the order of nanometer per second from shorter to longer wavelengths across several nanometers and fast backward jump. Recently, the dynamics of the SLLS in a Fabry-Perot cavity fiber laser was qualitatively described by a dynamic grating induced by spatial-hole-burning in the ytterbium doped fiber where the lifetime of the grating was related to the self-sustained relaxation oscillations. In this paper we address possible discrepancies between the published theoretical model and earlier observations of SLLS, particularly in fiber-ring lasers.We show that the qualitative theoretical model developed for explaining SLLS in the Fabry-Perot cavity can be used also to explain the SLLS effect we observed earlier in fiber-ring lasers