Summary. Background: Moderate hyperhomocysteinemia and B vitamins deficiency are thought to be risk factors for venous thromboembolism (VTE). The causality and independence of those associations are still questioned. Methods: We measured fasting serum total homocysteine, folates, and vitamin B12 levels as well as 5,10‐methylenetetrahydrofolate reductase (MTHFR) C677T genotypes in 467 patients hospitalized with a first well‐documented deep vein thrombosis and/or pulmonary embolism not related to a major acquired risk factor and 467 controls matched for gender and age. Results: Mild hyperhomocysteinemia, low serum folates, and vitamin B12 were associated with VTE independently of each other. In multivariate analysis, odds ratios (OR) (95% CI) for VTE associated with mild hyperhomocysteinemia (>15 μmol L−1), low serum folates (≤ 4.9 nmol L−1), and vitamin B12 (≤ 253 pmol L−1) were 1.48 (1.05–2.08), 3.14 (1.35–7.32) and 1.42 (1.03–1.98), respectively. An MTHFRC677T genotype was not significantly associated with VTE; OR (95% CI): 1.13 (0.70–1.81) Conclusions: The current data provides further knowledge in the complex relationship between hyperhomocysteinemia, low vitamin levels, and VTE.
The results of the Stewart-Fencl approach for interpretation of acid-base status can vary according to the analyzer used. These differences may have important clinical and research implications..
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