Several studies underscore the potential of deep learning in identifying complex patterns, leading to diagnostic and prognostic biomarkers. Identifying sufficiently large and diverse datasets, required for training, is a significant challenge in medicine and can rarely be found in individual institutions. Multi-institutional collaborations based on centrally-shared patient data face privacy and ownership challenges. federated learning is a novel paradigm for data-private multi-institutional collaborations, where model-learning leverages all available data without sharing data between institutions, by distributing the model-training to the data-owners and aggregating their results. We show that federated learning among 10 institutions results in models reaching 99% of the model quality achieved with centralized data, and evaluate generalizability on data from institutions outside the federation. We further investigate the effects of data distribution across collaborating institutions on model quality and learning patterns, indicating that increased access to data through data private multi-institutional collaborations can benefit model quality more than the errors introduced by the collaborative method. finally, we compare with other collaborative-learning approaches demonstrating the superiority of federated learning, and discuss practical implementation considerations. clinical adoption of federated learning is expected to lead to models trained on datasets of unprecedented size, hence have a catalytic impact towards precision/personalized medicine. Abbreviations CDS Collaborative data sharing FL Federated learning IIL Institutional incremental learning CIIL Cyclic institutional incremental learning IID Independent and identically distributed BraTS Brain tumor segmentation

Deep learning models for semantic segmentation of images require large amounts of data. In the medical imaging domain, acquiring sufficient data is a significant challenge. Labeling medical image data requires expert knowledge. Collaboration between institutions could address this challenge, but sharing medical data to a centralized location faces various legal, privacy, technical, and data-ownership challenges, especially among international institutions. In this study, we introduce the first use of federated learning for multi-institutional collaboration, enabling deep learning modeling without sharing patient data. Our quantitative results demonstrate that the performance of federated semantic segmentation models (Dice=0.852) on multimodal brain scans is similar to that of models trained by sharing data (Dice=0.862). We compare federated learning with two alternative collaborative learning methods and find that they fail to match the performance of federated learning.

Given the ability to directly manipulate image pixels in the digital input space, an adversary can easily generate imperceptible perturbations to fool a Deep Neural Network (DNN) image classifier, as demonstrated in prior work. In this work, we propose ShapeShifter, an attack that tackles the more challenging problem of crafting physical adversarial perturbations to fool image-based object detectors like Faster R-CNN. Attacking an object detector is more difficult than attacking an image classifier, as it needs to mislead the classification results in multiple bounding boxes with different scales. Extending the digital attack to the physical world adds another layer of difficulty, because it requires the perturbation to be robust enough to survive real-world distortions due to different viewing distances and angles, lighting conditions, and camera limitations. We show that the Expectation over Transformation technique, which was originally proposed to enhance the robustness of adversarial perturbations in image classification, can be successfully adapted to the object detection setting. ShapeShifter can generate adversarially perturbed stop signs that are consistently mis-detected by Faster R-CNN as other objects, posing a potential threat to autonomous vehicles and other safety-critical computer vision systems.

This exploratory study examined the rates of transformational, transactional, and laissez-faire leadership among academic library deans, directors, and university librarians to see if any differences in leadership styles existed by gender, age and experience of the leaders, and type of institution in which they worked. The study found no differences between male and female leaders, but women were more likely to use idealized attributes and inspirational motivation, both skills of transformational leaders. The study found no difference in leadership styles by type of institution but did find a strong correlation between the number of years of administrative experience and the use of transactional leadership.

Although machine learning (ML) has shown promise across disciplines, out-of-sample generalizability is concerning. This is currently addressed by sharing multi-site data, but such centralization is challenging/infeasible to scale due to various limitations. Federated ML (FL) provides an alternative paradigm for accurate and generalizable ML, by only sharing numerical model updates. Here we present the largest FL study to-date, involving data from 71 sites across 6 continents, to generate an automatic tumor boundary detector for the rare disease of glioblastoma, reporting the largest such dataset in the literature (n = 6, 314). We demonstrate a 33% delineation improvement for the surgically targetable tumor, and 23% for the complete tumor extent, over a publicly trained model. We anticipate our study to: 1) enable more healthcare studies informed by large diverse data, ensuring meaningful results for rare diseases and underrepresented populations, 2) facilitate further analyses for glioblastoma by releasing our consensus model, and 3) demonstrate the FL effectiveness at such scale and task-complexity as a paradigm shift for multi-site collaborations, alleviating the need for data-sharing.