AB STRACT:The ef fi cacy of the flu o ride-chlorhexidine as so ci a tion in the pre ven tion of gin gi vi tis and car ies has been advo cated for a num ber of years 5,7,14 . The ob jec tive of the as so ci a tion of these ther a peu tic agents is a syn er gis tic ac tion. The aim of the pres ent study was to de ter mine the substantivity of chlorhexidine as so ci ated or not to so dium flu o ride at dif fer ent in ter vals of time, in vi tro. Bo vine enamel sur faces were treated with 0.12% chlorhexidine gluconate (Periogard ® -Colgate ® ) or 0.05% so dium flu o ride with 0.12% chlorhexidine (Duplak ® -Dentsply ® ) so lu tions for one min ute. Frag ments were placed in dis tilled wa ter and sam ples were col lected at in ter vals of 5, 30 and 360 min utes and an a lyzed by spectrophotometry in the vis i ble ul tra vi o let re gion. Substantivity was eval u ated by the mea sure ment of chlorhexidine desorption from the treated slabs. The mean val ues ob tained were sta tis ti cally an a lyzed by Stu dent's t-test. The re sults showed that the con cen tra tion of chlorhexidine de creased when it was used in as so ci a tion with sodium flu o ride. The dif fer ence be tween the groups was sta tis ti cally sig nif i cant (p < 0.05). These in vi tro re sults sug gest that the as so ci a tion be tween so dium flu o ride and chlorhexidine in the stud ied con cen tra tions ap pears to have no bene fi cial ef fect be cause of the de crease in the substantivity of chlorhexidine. DESCRIPTORS:Chlor he xi di ne; So di um flu o ri de; Subs tan ti vity. RESUMO:A efe ti vi da de da as so ci a ção flu o re to-clo re xi di na na pre ven ção da gen gi vi te e da cá rie vem sen do de fen di da há al guns anos 5,7,14 . O pro pó si to des sa as so ci a ção é ob ter um de sem pe nho si nér gi co. O ob je ti vo do pre sen te es tu do foi ava li ar a subs tan ti vi da de da clo re xi di na em as so ci a ção ou não ao flu o re to de só d io em di fe ren tes in ter va los de tem po, in vi tro. Fo ram tra ta das su per fí ci es de es mal te bo vi no com so lu ções de di glu co na to de clo re xi di na 0,12% (Pe ri o gard ® -Col ga te ® ) ou flu o re to de só dio 0,05% com clo re xi di na 0,12% (Du plak ® -Dentsply ® ), du ran te um mi nu to. A subs tan ti vida de foi me di da pela des sor ção da clo re xi di na a par tir dos frag men tos pre vi a men te imer sos nas so lu ções tes te e co loca dos em água des ti la da. Alí quo tas fo ram re mo vi das em in ter va los de 5 mi nu tos, 30 mi nu tos e 6 ho ras e ana li sa das atra vés de es pec tros co pia na re gião do ul tra vi o le ta vi sí vel. Os va lo res ob ti dos fo ram ana li sa dos es ta tis t i ca men te pelo tes te t de Stu dent. Os re sul ta dos mos tra ram que a con cen tra ção da clo re xi di na foi sig ni fi c a ti va men te re du zi da quan do em as so ci a ção com flu o re to de só dio (p < 0,05). Os re sul ta dos in vi tro su ge rem que a as so ci a ção da clo re xi di na ao flu ore to de só dio nas con cen tra ções es tu da das pa re ce não ter efe i to be né fi co, de vi do...
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