Pemphigus vulgaris is an autoimmune disease characterized by suprabasal blisters with
acantholysis, which has a fatal course in a large number of untreated patients.
Systemic corticosteroid therapy is considered first-line therapy. Adjuvant treatment
with the goal of sparing corticosteroids include, among others, dapsone. This drug is
not without side effects and its use requires clinical and laboratory control. We
present a patient with PV initially managed with suboptimal dose of prednisone,
evolving into drug-induced hepatitis after introduction of dapsone.
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