This
work is focused on the study of the effect of cholesterol
on the properties of vesicular membranes of ionic amphiphilic pairs
at different temperatures. The hexadecyltrimethylammonium-dodecyl
sulfate ionic amphiphilic pair system with the addition of 10 mol
% dioctadecyldimethylammonium chloride was chosen for a detailed study
of vesicle properties. A large range of cholesterol concentrations
(0–73 mol %) in the temperature range 10–80 °C
was studied. Under these conditions, the size distribution, the membrane
fluidity, and the surface layer were monitored together with the change
in the mobility of water in the surface layer. Obtained quantities
were correlated with each other and combined into appropriate graphs.
It was found that in stable systems that meet the condition of unimodal
size distribution with a PDI value lower than 0.3, temperature has
virtually no effect on the size of vesicular systems. On the contrary,
when studying the hydration and fluidity of the membrane, significant
changes in these parameters were found, which, however, do not affect
the short-term stability of these vesicular systems. The presented
results thus indicate the possibility of adjusting the composition
of the vesicular system in terms of fluidity and membrane hydration
while maintaining short-term stability and size distribution.
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