This paper documents the seventeenth data release (DR17) from the Sloan Digital Sky Surveys; the fifth and final release from the fourth phase (SDSS-IV). DR17 contains the complete release of the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey, which reached its goal of surveying over 10,000 nearby galaxies. The complete release of the MaNGA Stellar Library accompanies this data, providing observations of almost 30,000 stars through the MaNGA instrument during bright time. DR17 also contains the complete release of the Apache Point Observatory Galactic Evolution Experiment 2 survey that publicly releases infrared spectra of over 650,000 stars. The main sample from the Extended Baryon Oscillation Spectroscopic Survey (eBOSS), as well as the subsurvey Time Domain Spectroscopic Survey data were fully released in DR16. New single-fiber optical spectroscopy released in DR17 is from the SPectroscipic IDentification of ERosita Survey subsurvey and the eBOSS-RM program. Along with the primary data sets, DR17 includes 25 new or updated value-added catalogs. This paper concludes the release of SDSS-IV survey data. SDSS continues into its fifth phase with observations already underway for the Milky Way Mapper, Local Volume Mapper, and Black Hole Mapper surveys.

Star-forming galaxies can in principle be transformed into passive systems by a multitude of processes that quench star formation, such as the halting of gas accretion (starvation) or the rapid removal of gas in AGN-driven outflows. However, it remains unclear which processes are the most significant, primary drivers of the SF-passive bimodality. We address this key issue in galaxy evolution by studying the chemical properties of 80 000 local galaxies in Sloan Digital Sky Survey Data Release 7. In order to distinguish between different quenching mechanisms, we analyse the stellar metallicities of star-forming, green valley, and passive galaxies. We find that the significant difference in stellar metallicity between passive galaxies and their star-forming progenitors implies that for galaxies at all masses, quenching must have involved an extended phase of starvation. However, some form of gas ejection also has to be introduced into our models to best match the observed properties of local passive galaxies, indicating that, while starvation is likely to be the prerequisite for quenching, it is the combination of starvation and outflows that is responsible for quenching the majority of galaxies. Closed-box models indicate that the duration of the quenching phase is 2–3 Gyr, with an e-folding time of 2–4 Gyr, after which further star formation is prevented by an ejective/heating mode. Alternatively, leaky-box models find a longer duration for the quenching phase of 5–7 Gyr and an e-folding time of ∼1 Gyr, with outflows becoming increasingly important with decreasing stellar mass. Finally, our analysis of local green valley galaxies indicates that quenching is slower in the local Universe than at high redshift.

We investigate how star formation quenching proceeds within central and satellite galaxies using spatially resolved spectroscopy from the SDSS-IV MaNGA DR15. We adopt a complete sample of star formation rate surface densities (ΣSFR), derived in Bluck et al. (2020), to compute the distance at which each spaxel resides from the resolved star forming main sequence (ΣSFR − Σ* relation): ΔΣSFR. We study galaxy radial profiles in ΔΣSFR, and luminosity weighted stellar age (AgeL), split by a variety of intrinsic and environmental parameters. Via several statistical analyses, we establish that the quenching of central galaxies is governed by intrinsic parameters, with central velocity dispersion (σc) being the most important single parameter. High mass satellites quench in a very similar manner to centrals. Conversely, low mass satellite quenching is governed primarily by environmental parameters, with local galaxy over-density (δ5) being the most important single parameter. Utilising the empirical MBH - σc relation, we estimate that quenching via AGN feedback must occur at MBH ≥ 106.5 − 7.5M⊙, and is marked by steeply rising ΔΣSFR radial profiles in the green valley, indicating ‘inside-out’ quenching. On the other hand, environmental quenching occurs at over-densities of 10 - 30 times the average galaxy density at z∼0.1, and is marked by steeply declining ΔΣSFR profiles, indicating ‘outside-in’ quenching. Finally, through an analysis of stellar metallicities, we conclude that both intrinsic and environmental quenching must incorporate significant starvation of gas supply.

Safe and effective immunologic adjuvants are often essential for vaccines. However, the choice of adjuvant for licensed vaccines is limited, especially for those that are administered intradermally. We show that non-tissue damaging, near-infrared (NIR) laser light given in short exposures to small areas of skin, without the use of additional chemical or biological agents, significantly increases immune responses to intradermal influenza vaccination without augmenting IgE. The NIR laser-adjuvanted vaccine confers increased protection in a murine influenza lethal challenge model as compared to unadjuvanted vaccine. We show that NIR laser treatment induces the expression of specific chemokines in the skin resulting in recruitment and activation of dendritic cells and is safe to use in both mice and humans. The NIR laser adjuvant technology provides a novel, safe, low-cost, simple-to-use, potentially broadly applicable and clinically feasible approach to enhancing vaccine efficacy as an alternative to chemical and biological adjuvants.

We present a reduction and analysis of the James Webb Space Telescope (JWST) SMACS 0723 field using new post-launch calibrations to conduct a search for ultra-high-redshift galaxies (z > 9) present within the Epoch of Reionisation. We conduct this search by modelling photometric redshifts in several ways for all sources and by applying conservative magnitude cuts (mF200W < 28) to identify strong Lyman breaks greater than 1 magnitude. We find four z > 9 candidate galaxies which have not previously been identified, with one object at z = 11.5, and another which is possibly a close pair of galaxies. We measure redshifts for candidate galaxies from other studies and find the recovery rate to be only 23 per cent, with many being assigned lower redshift, dusty solutions in our work. Most of our z > 9 sample show evidence for Balmer-breaks, or extreme emission lines from Hβ and [OIII], demonstrating that the stellar populations could be advanced in age or very young depending on the cause of the F444W excess. We discuss the resolved structures of these early galaxies and find that the Sérsic indices reveal a mixture of light concentration levels, but that the sizes of all our systems are exceptionally small (<0.5 kpc). These systems have stellar masses M* ∼ 109.0 M⊙, with our z ∼ 11.5 candidate a dwarf galaxy with a stellar mass M* ∼ 107.8 – 108.2 M⊙. These candidate ultra high-redshift galaxies are excellent targets for future NIRSpec observations aimed to better understand their physical nature.