Fifty-nine drug addicts and alcoholics were treated with clothiapine for a period up to 2 months for alleviation of their withdrawal symptoms. Most of the patients cooperated with the treatment, and this was due to the very few side effects that were experienced by them. The patients were completely withdrawn from physical dependence on drugs and we were able to discharge them without an irresistible impulse for the drug.
The study is concerned with alcoholismi and drug depedence a6 causal and as associated factors in psychiatric hospital admiseions in New South Wales. During the 1966-1970 period, the only significant increase among first admissions occurred in the 10 to 19 age group: the proportion of
the 100-point HRQOL measure, where a higher number indicates higher disease burden. Overall, these hydrotherapies produced a moderate reduction of pain on the VAS (9 trials; N5318, SMD -0.78; 95% CI, -1.42 to -0.13; I 2 583%) and largely improved quality of life on the HRQOL (4 trials; SMD5-1.67; 95% CI, -2.91 to -0.43; I 2 590%). These effects were sustained at follow-up (follow-up was at 6-36 weeks, median 14), with a large pain reduction persisting on the VAS (4 trials; N5160, SMD -1.27; 95% CI, -2.15 to -0.38; I 2 584%) and a large improvement in quality of life persisting on the HRQOL (4 trials; N5202, SMD -1.16; 95% CI, -1.96 to -0.36; I 2 584%). Subgroup analysis for pain improvement indicated statistical significance only in the RCTs involving bathing in thermal or mineral water (5 trials; N5184; P,.0001; SMD -1.63; 95% CI, -.231 to -0.96; I 2 573%), whereas trials with whirl baths, mud baths, and Stanger bath did not (3 trials; N5134, SMD 0.01; 95% CI, -0.45 to 0.47; I 2 512). Only one RCT reported side effects, with a 10% incidence of slight "flushing." This paper was limited by the absence of intention-totreat analysis or adequate blinding in any studies, by only three RCTs having sample sizes of at least 25 per group, and by the method of randomization generally not being reported.The opinions and assertions contained herein are those of the authors and are not to be construed as official or as reflecting the views of the US Army Medical Department, the Army at large, or the Department of Defense.
Findings-of research (conducted mainly by outsiders of the programs) have accumulated, which showed that the dissemination of drug knowledge not only does not prevent but could actually encourage drug experimentation by juveniles. Although a new ideology, which stresses education about 'effective living' instead of about drugs, has been propagated for a number of years now, its presumed prophylactic effects have yet to be demonstrated by its supporters. It is argued here that a continued reliance by professionals on empirically un validated educational programs, based on common sense and intuitive notions, constitutes an abrogation of professional responsibility;also, that at the present state of knowledge, the cutting off of drug supplies and possibly an attenuation of drug related publicity might be the only effective measures for primary and secondary prevention of drug abuse by children and juveniles.
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