Racial and ethnic achievement gaps narrowed substantially in the 1970s and 1980s. As some of the gaps widened in the 1990s, there were some setbacks in the progress the nation made toward racial and ethnic equity. This article offers a look below the surface at Black-White and Hispanic-White achievement gap trends over the past 30 years. The literature review and data analysis identify the key factors that seem to have contributed to bifurcated patterns in achievement gaps. The conventional measures of socioeconomic and family conditions, youth culture and student behavior, and schooling conditions and practices might account for some of the achievement gap trends for a limited time period or for a particular racial and ethnic group. However, they do not fully capture the variations.This preliminary analysis of covariations in racial and ethnic gap patterns across several large data sets has implications for future research on the achievement of minority groups.

The pathological hallmark of synucleinopathies, including Lewy body dementia and Parkinson’s disease (PD), is the presence of Lewy bodies, which are primarily composed of intracellular inclusions of misfolded α-synuclein (α-syn) among other proteins. α-Syn is found in extracellular biological fluids in PD patients and has been implicated in modulating immune responses in the central nervous system (CNS) and the periphery. Natural killer (NK) cells are innate effector lymphocytes that are present in the CNS in homeostatic and pathological conditions. NK cell numbers are increased in the blood of PD patients and their activity is associated with disease severity; however, the role of NK cells in the context of α-synucleinopathies has never been explored. Here, we show that human NK cells can efficiently internalize and degrade α-syn aggregates via the endosomal/lysosomal pathway. We demonstrate that α-syn aggregates attenuate NK cell cytotoxicity in a dose-dependent manner and decrease the release of the proinflammatory cytokine, IFN-γ. To address the role of NK cells in PD pathogenesis, NK cell function was investigated in a preformed fibril α-syn–induced mouse PD model. Our studies demonstrate that in vivo depletion of NK cells in a preclinical mouse PD model resulted in exacerbated motor deficits and increased phosphorylated α-syn deposits. Collectively, our data provide a role of NK cells in modulating synuclein pathology and motor symptoms in a preclinical mouse model of PD, which could be developed into a therapeutic for PD and other synucleinopathies.

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15537. In addition to this overview, in which are identified ‘Other protein targets’ which fall outside of the subsequent categorisation, there are six areas of focus: G protein‐coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

This article examines whether performance-driven educational accountability policy enhances or hinders equity. Combining data from state policy surveys, F-33, SASS, and NAEP, the article shows that during the 1990s, the states did not address racial and socioeconomic disparities in school resources and failed to narrow the achievement gaps among racial and socioeconomic groups. The distributions of school expenditures, class size, qualified teachers, and mathematics achievement remained largely unchanged in strong accountability states. Although the accountability policy of the 1990s neither produced adverse effects nor brought about significant setbacks in equity, this article suggests that racial and socioeconomic equity were not at the center of accountability reforms and that performance-driven accountability policies alone cannot move us forward toward equity.

This study examines the impact of high-stakes school accountability, capacity, and resources under NCLB on reading and math achievement outcomes through comparative interrupted time-series analyses of 1990–2009 NAEP state assessment data. Through hierarchical linear modeling latent variable regression with inverse probability of treatment weighting, the study addresses pre-NCLB differences in state characteristics and trends to account for variations in post-NCLB gains. While the states’ progress was uneven among different grades, subjects, and subgroups, NCLB did not yet evidence sustainable and generalizable high-stakes accountability policy effects. Improving average achievement as well as narrowing achievement gaps was associated with long-term statewide instructional capacity and teacher resources rather than short-term NCLB implementation fidelity, rigor of standards, and state agency’s capacity for data tracking and intervention.