PurposeTo evaluate choroidal thickness in diabetes patients using spectral-domain optical coherence tomography.MethodsWe examined 203 eyes of 203 diabetic participants and 48 eyes of 48 healthy controls. The choroidal thickness at the foveal lesion was measured by enhanced-depth imaging optical coherence tomography. The participants were grouped according to diabetic retinopathy grade: no diabetic change, mild-to-moderate or severe non-proliferative, or proliferative diabetic retinopathy. The study parameters included history, age, axial length, intraocular pressure, central retinal thickness, fasting glucose, and blood pressure.ResultsThe subfoveal choroidal thickness was thinner in eyes with non-proliferative or proliferative diabetic retinopathy than in normal eyes (p < 0.01). However, there was no difference between eyes with non-proliferative and proliferative diabetic retinopathy or between eyes with no diabetic change and the controls. Eyes exhibiting macular edema showed no significant difference in choroidal thickness compared with eyes having normal macular contours.ConclusionsThe central choroid is thinner when eyes show diabetic changes on the retina. However, the presence of diabetic macular edema or proliferative change is not associated with more pronounced choroidal thinning.

Vascular endothelial growth factor and IL-8 were not increased in the aqueous humor and plasma of patients with CSC. The effect of intravitreal bevacizumab injection as a treatment for CSC must be fully understood, and the true effect of anti-VEGF treatment in patients with CSC remains to be elucidated.

The mode-coupling properties of tunable long-period fiber gratings (LPGs) formed in photonic crystal fibers (PCFs) are presented. The mode coupling from the fundamental core mode to a cladding mode of a PCF is obtained by use of periodic mechanical pressure. The strength and the wavelength of the resonant peak are tuned by adjusting the grating period and the pressure applied on the PCF. Contrary to the conventional fiber case, the resonant wavelength of the PCF LPG is decreased by increasing the periodicity.

We demonstrate implementation of an all-fiber Mach-Zehnder interferometer formed in a photonic crystal fiber (PCF). We formed the all-PCF Mach-Zehnder interferometer by mechanically inducing two identical long-period fiber gratings (LPGs) in the PCF. The spectral properties of a LPG and a LPG pair were investigated. The interference fringe formed within the stop band of the LPG pair varied with the period and the strength of the gratings, and the fringe spacing was decreased with increasing grating separation. From the fringe spacing measurement the differential effective group index of the PCF was calculated to be deltam approximately equal to 2.8 x 10(-3).