Phenazine-1-carboxylic acid (Ia) and 6-(3-methyl-2-butenyl)phenazine-1-carboxylic acid (IIa) were isolated from the mycelium of the strain Streptomyces cinnamonensis ATCC 15 413. Identification and structure elucidation were performed by spectroscopic methods. Both compounds weakly inhibit the growth of gram-positive bacteria.
mM to a submerged culture of Streptomyces cinnamonensis caused partial inhibition of total monensin biosynthesis and coproduction of new metabolites, 26-deoxymonensins A and B. The latter was isolated as its 25-0-methyl derivative. Metyrapone was simultaneously reduced to metyrapol. All of these compounds were identified by nuclear magnetic resonance spectroscopy and mass spectrometry.
Analytical and preparative high-performance liquid chromatography of 3 phenazines and furonaphthoquinone derivative on reversed-phase column are described. The mobile phase was methanol and water. The injected amount of the mixture was about 30 mg for a preparative chromatographic run requiring 80 min. Substances were detected directly in the column effluent by UV detection.
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