Postauricular injection shows potential as an efficient drug delivery route for the treatment of inner ear disorders.
Our meta-analysis demonstrates that genistein significantly reduces homocysteine levels and increases HDL cholesterol levels in postmenopausal women. Genistein also significantly decreases LDL cholesterol, total cholesterol and triglyceride levels in postmenopausal women with metabolic syndrome.
Introduction To evaluate the utility of the ring pulse oximeter for screening of OSA in adults. Methods 87 adults were monitored by a ring pulse oximeter and PSG simultaneously during a nocturnal in-lab sleep testing. 3% oxygen desaturation index (ODI3); Mean oxygen saturation(MSpO2), Saturation impair time below 90% (SIT90) derived from an automated algorithm of the ring pulse oximeter. Meanwhile, the parameters of PSG were scored manually according to the AASM Manual. Correlation and receiver operator characteristic curve analysis were used to measure the accuracy of ring pulse oximeter and its diagnostic value for moderate to severe OSA (AHI≥15). Results Among the 87 participants, 18 cases were AHI<5, 17 cases were diagnosed with mild OSA (AHI:5-14.9), 25 cases were diagnosed with moderate OSA (AHI:15-29.9) and 27 cases were diagnosed with severe OSA (AHI≥30). There was no significant difference between PSG and ring pulse oximeter in regard to ODI3 (23.4±23.5 vs 24.7 ± 21.7), and SIT90 (1.54%, range 0.14%-8.99% vs. 3.20%, range 0.60%, 12.30%) (P>0.05], Further analysis indicated that two parameters from the oximeter correlated well with that derived from PSG (r=0.889, 0.567, respectively, both p<0.05). Although MSpO2 correlated significantly (r=0.448, P<0.05), the difference was remarkable [95.9%, range 94.0% to 97.0% vs. 94.5%, range 93.3% to 95.7%, p<0.05]. Bland-Altman plots showed that the agreement of these three parameters was within the clinical acceptance range. The ROC curve showed that the sensitivity and specificity of the ring pulse oximeter when the oximeter derived ODI3 ≥12.5 in the diagnosis of moderate to severe OSA were 82.7% and 74.3%, respectively. Conclusion The pilot study indicated that ring pulse oximeter can detect oxygen desaturation events accurately, therefore to be used as a screening tool for moderate to severe OSA. Support The study was supported by the National Natural Science Foundation of China (No. 81420108002 and NO. 81570083).
BackgroundRheumatoid arthritis (RA) is a prevalent systemic autoimmune disease characterized by the production of autoantibodies1. The tonsil has been demonstrated to be a site of citrullination, and tonsillectomy has been reported to be a potential treatment of RA, suggesting the possibility that the tonsil could be a site of autoimmunity generation in RA2,3. The dysbiosis of gut microbiome and the associated host immune response has been implicated in the initiation and progression of RA4–6. However, there is no in-depth studies on the role of tonsil microbiota in RA. Thus, studies of the characteristics of tonsil microbiome in RA patients, the underlying mechanisms, as well as specific markers for the diagnosis and therapeutic evaluation for RA, are critical for the early diagnosis and prevention of RA.ObjectivesTherefore, we aimed to define the association of RA with tonsil microbiome as well as a microbial and metabolite profile that could predict disease status.Methods16S rRNA gene sequencing was utilized on 220 tonsil swab samples (121 RA patients and 99 healthy controls) as well as 78 fecal samples (68 RA and 10 controls). Analysis of microbial taxa and metabolic pathway were performed to characterise and compare the tonsil microbiome of RA patients and healthy subjectsResultsResults showed that the tonsil harbored a unique microbiome relative to that present in the fecal samples. Patients with RA exhibited different tonsil microbiome from controls. A taxon-level analysis suggested that the relative abundance of 26 microbial clades were significantly altered, with 7 taxa increased and 19 taxa decreased in RA samples. Noticeably, we observed an expansion of rare microbial lineages as well as an alteration in microbial cladogenesis within RA patients. RA tonsil microbiota was associated with smoke, anti-peripheral factor, rheumatoid factors, disease duration and activity. Furthermore, we identified that 86 genes associated with bacterial metabolic pathway were enriched in RA tonsil microbiome.ConclusionsOur results demonstrated that the RA tonsil microbiome differs from that of healthy controls, which correlates with systemic autoimmune changes and may potentially drives initiation of RA.References McInnes IB, and Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011, 365(23): 2205–2219.Kawano M, Okada K, Muramoto H, et al. Simultaneous, clonally identical T cellexpansion in tonsil and synovium in a patient with rheumatoid arthritis and chronic tonsillitis. Arthritis Rheum. 2003, 48(9): 2483–2488.Makrygiannakis D, af Klint E, Lundberg IE, et al. Citrullination is an inflammation-dependent process. Ann Rheum Dis. 2006, 65(9): 1219–1222.Scher JU and Abramson SB. The microbiome and rheumatoid arthritis. Nat Rev Rheumatol, 2011, 7(10): 569–578.Scher JU, Sczesnak A, Longman RS, et al. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife, 2013, 2:e01202.Zhang X, Zhang D, Jia H, et al. The oral and gut microbiomes are perturbed in rheumatoid arthritis...
BackgroundSome publications shows some therapies in rheumatoid arthritis (RA) could cause infections and it also can react the disease prognosis. But there was no report about the relationship between the repeated infections during the disease duration and its outcome.ObjectivesOur study was to evaluate the association between the history of repeated infectious agents that occurred more than three times during the duration of RA and the current disease status of RA, such as disease activity and physical disability.Methods688 pure RA patients were selected from December 2015 to June 2016 in Peking People's hospital and divided into two groups according to their current disease status. Clinical data were collected including DAS28, HAQ, disease duration and therapies. Infectious agents occurred repeatedly during the duration were identified as history repeated infectious agents. T test, ANOVA, chi-squared test and multivariate analysis of covariance were used for analyzing the association between the infections and disease outcome.Results688 RA patients were divided into two groups based on whether their DAS28 reached 3.2 (active or inactive). The HAQ score and the incidence of airway infection has a significant difference among these two groups (P=0.000; P=0.002). Logistic regression analysis shows that smoking, airway infection and age were the risk factor for RA activite (OR=4.844, 95% CI (0.193,1.001); OR=1.326, 95% CI (0.655,2.687); OR=1.013, 95% CI (0.989,1.037)), and the disease duration and the therapy were also effect the disease outcome (OR=0.650;OR=1.560). Than we divided these patients into four groups based on their infectious site such as airway, urinary, intestinal and no-infection. After adjusting for the disease duration, only airway infection incidence has statistically significantly different (P=0.000). DAS 28 has statistical different only among the groups whether they have airway infectious agents after adjusting the smoking and therapy (P=0.002; P=0.002). Compared with infection free group, patients with airway infection has a higher DAS28 because they have more swollen or painful joints, while patients with urinary infection perform a higher scores because they have a high level of ESR.ConclusionsThe repeated infectious agents during the disease duration might lead to poor outcome. We should pay more attention to those patients who have repeatedly infectious agents during their disease duration in order to improve their prognosis.References Sokolove J, Wagner CA, Lahey LJ, et al. Increased inflammation and disease activity among current cigarette smokers with rheumatoid arthritis: a cross-sectional analysis of US veterans. Rheumatology (Oxford). 2016;55(11):1969–77.Sokolove J, Wagner CA, Lahey LJ, et al. Increased inflammation and disease activity among current cigarette smokers with rheumatoid arthritis: a cross-sectional analysis of US veterans. Rheumatology (Oxford). 2016;55(11):1969–77.Iguchi-Hashimoto M, Hashimoto M, Fujii T, et al. The association between serious infection and disease out...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.