Despite magnetic hyperthermia being considered one of the most promising techniques for cancer treatment, until now spherical magnetite (Fe 3 O 4 ) or maghemite (γ-Fe 2 O 3 ) nanoparticles, which are the most commonly employed and only FDA approved materials, yield the limited heating capacity. Therefore, there is an increasing need for new strategies to improve the heating efficiency or the specific absorption rate (SAR) of these nanosystems. Recently, a large improvement in SAR has been reported for nanocubes of Fe 3 O 4 relative to their spherical counterpart, as a result of their enhanced surface anisotropy and chainlike particle formation. Considering the proven advantages of high aspect ratio onedimensional (1D) Fe 3 O 4 nanostructures over their spherical and cubic counterparts, such as larger surface area, multisegmented capabilities, enhanced blood circulation time, and prolonged retention in tumors, we propose a novel approach that utilizes this 1D nanostructure for enhanced hyperthermia. Here, we demonstrate that the SAR of iron oxide nanostructures can be enhanced and tuned by altering their aspect ratio. Calorimetric and ac magnetometry experiments performed for the first time on highly crystalline Fe 3 O 4 nanorods consistently show large SAR values (862 W/g for an ac field of 800 Oe), which are superior to spherical and cubic nanoparticles of similar volume (∼140 and ∼314 W/g, respectively). Increasing the aspect ratio of the nanorods from 6 to 11 improves the SAR by 1.5 times. The nanorods are rapidly aligned by the applied ac field, which appreciably increases the SAR values. A detailed analysis of the effect of the alignment of the nanorods in agar indicates an appreciable SAR increase up to 30% when the nanorods are parallel to the field. These findings pave a new pathway for the design of novel high-aspect ratio magnetic nanostructures for advanced hyperthermia.

Heusler alloy Mn 50 Ni 40 In 10 was produced as preferentially textured ribbon flakes by melt spinning, finding the existence of martensitic-austenic transformation with both phases exhibiting ferromagnetic ordering. A microcrystalline three-layered microstructure of ordered columnar grains grown perpendicularly to ribbon plane was formed between two thin layers of smaller grains. The characteristic temperatures of the martensitic transformation were M S = 213 K, M f = 173 K, A S = 222 K, and A f = 243 K. Austenite phase shows a cubic L2 1 structure ͑a = 0.6013͑3͒ nm at 298 K and a Curie point of 311 K͒, transforming into a modulated fourteen-layer modulation monoclinic martensite. © 2008 American Institute of Physics. ͓DOI: 10.1063/1.2827179͔Since Sutou et al.1 reported the occurrence of martensitic transformation in the ferromagnetic Heusler system Ni 50 Mn 50−x In x , considerable attention has been dedicated to study magnetism and magnetic shape memory effect, [2][3][4] magnetic entropy change, [4][5][6][7][8] and magnetotransport properties 9-11 of these alloys. Nevertheless, ferromagnetism in both phases is only observed in the narrow composition range of 15ഛ x ഛ 16 2 . The characteristic temperatures of the reversible first order structural transformation between both phases, referred as martensitic and austenitic starting and finish temperatures ͑i.e., M S , M f , A S , and A f , respectively͒, strongly vary upon small changes in the chemical composition. The crystal structure of austenite and martensite depends on the composition, 2,4 and the transformation can be also induced by applying a magnetic field.2-4 Additionally, a large inverse and direct magnetocaloric effect has been measured in Ni 50 Mn 34 In 16 .6-8 Ni-Mn-In Heusler alloys are therefore of significant prospective importance for applications in both magnetically driven actuators due to magnetic shape memory effect and as working substances in magnetic refrigeration technology.Until now, the investigated alloys are usually bulk polycrystals obtained by arc or induction melting followed by a high temperature annealing, [1][2][3][4][5][6][7][8]10 or single crystals grown by Czochralski method.9,11 Present investigation was carried out to employ rapid quenching by melt spinning to produce MnNi-In Heusler alloys. This technique offers two potential advantages for the fabrication of these magnetic shape memory alloys: the avoiding, or reduction, of the annealing to reach a homogeneous single phase alloy, and the synthesis of highly textured polycrystalline ribbons. Ribbon shape can be also appropriate for use in practical devices. We fabricated the alloy Mn 50 Ni 40 In 10 by melt spinning. Its valence electronic concentration per atom e / a is 7.801, allowing the existence of martensite-austenite transformation with both phases exhibiting ferromagnetic ordering, opening its potential use as a magnetic shape memory alloy. 3 We report in this letter a preliminary characterization of the microstructural features and magnetic behavior.As-cast pel...

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