Summary The Cancer Genome Atlas (TCGA) project has analyzed mRNA expression, miRNA expression, promoter methylation, and DNA copy number in 489 high-grade serous ovarian adenocarcinomas (HGS-OvCa) and the DNA sequences of exons from coding genes in 316 of these tumors. These results show that HGS-OvCa is characterized by TP53 mutations in almost all tumors (96%); low prevalence but statistically recurrent somatic mutations in 9 additional genes including NF1, BRCA1, BRCA2, RB1, and CDK12; 113 significant focal DNA copy number aberrations; and promoter methylation events involving 168 genes. Analyses delineated four ovarian cancer transcriptional subtypes, three miRNA subtypes, four promoter methylation subtypes, a transcriptional signature associated with survival duration and shed new light on the impact on survival of tumors with BRCA1/2 and CCNE1 aberrations. Pathway analyses suggested that homologous recombination is defective in about half of tumors, and that Notch and FOXM1 signaling are involved in serous ovarian cancer pathophysiology.

No abstract

Patients with VVR had changes in CBF velocity, which are different from those presented by patients with POTS and OI pattern. Cerebral blood flow monitoring is useful to increase the yield of HUT and may allow early interruption before syncope occurs, reducing patient discomfort.

No abstract

El cáncer primario de salpinge uterina es una neoplasia maligna rara del aparato genital femenino, corresponde al 0.1 a 1.8% de las neoplasias malignas ginecológicas. Se presenta sobre todo en pacientes menopáusicas o post menopáusicas, con mayor incidencia entre los 55-65 años de edad. Presentamos el caso de una paciente de 45 años de edad con el diagnostico de carcinoma primario de salpinge siendo que la paciente acude a consulta por dolor abdominal y presencia de flujo vaginal, con reporte ecográfico de masa anexial derecha, es ingresada a cirugía con el diagnóstico pre-operatorio de “tumor de ovario derecho”, se realiza estudio trans-operatorio mismo que descarta lesión en ovario y postula lesión neoplásica primaria de salpinge , llegando al diagnóstico definitivo por histopatología e inmunohistoquimica de carcinoma seroso de alto grado, afecta capa muscular sin rebasarla. Asociado a focos de TIC (carcinoma intratubario). En ovario se evidenció: ocarcinoma seroso de alto grado metástasico de salpinge.