SYNOPSIS
Plasma levels of immunoreactive b‐endorphin were found to be lower in patients with classical migraine than in patients with common migraine or chronic daily vascular headache or the control group. A role for b‐endorphin in the mechanism of the neurological dysfunction in classical migraine is suggested.
DNA coding for the opiate peptide beta-endorphin has been cloned into bacterial plasmids in such a way as to direct the synthesis of a hybrid beta-galactosidase/beta-endorphin protein. This hybrid protein can readily be cleaved in vitro to release biologically active beta-endorphin.
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