The conformational equilibrium constants for a series of 1-alkyl substituted cyclohexanols have been determined using a lanthanide shift reagent, and the results compared with other methods. In comparison to other techniques greater preference is shown by the hydroxyl group for the equatorial position. This is rationalized by the effect on the equilibrium of the bulky shift reagent.
All of the compounds gave elemental analyses (C, , N, S) within ±0.30 of the calculated values.was dissolved in acetone (20.0 ml) and the solution was cooled in freezing mixtures. To this cooled solution, phenylcyanamide hydrochloride (2.4 g, 0.015 mol) dissolved In acetone (10.0 ml) was added slowly with constant shaking. After keeping it in a freezing mixture for 1 h, crystalline pure /V-phenylformamidino-A/'-dlmethylthiosemicarbazone hydrochloride was separated, filtered, and washed with acetone and petroleum ether to remove any unreacted constituents, yield 3.3 g, 80 %, mp 203-204.Other AA-arylformamidino-N'-dimethlthiosemlcarbazone hydrochlorides, prepared by condensing dimethylthiosemlcarba-zone with different arylcanamides hydrochloride are summarized in Table I.Using similar procedure as above several /V-arylformamidino-A/'-diphenylthiosemicarbazone hydrochlorides, described in Table II, were obtained.
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