The use of YL-577 as an alternative approach for PRP reduces pain perception and is preferred by patients. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:902-905.].
Introducción: El tabaquismo y la nicotina son factores de riesgo conocidos para diversas enfermedades cardiovasculares, por lo que es de esperar que estos se asocien a cambios vasculares en diversas partes del organismo, incluyendo la vasculatura coroidea. Objetivo: Evaluar los efectos que tiene la nicotina en el grosor coroideo en pacientes sanos medido mediante la tomografía de coherencia óptica con imagen de profundidad mejorada (EDI-OCT). Material y métodos: Estudio de casos y controles, en el cual se midió el grosor coroideo a sujetos sanos tras consumir una goma de mascar con 4 mg de nicotina y se comparó con un grupo control al cual se le administró una goma de mascar sin nicotina. Para la estadística descriptiva se utilizaron frecuencias, medias y desviación estándar. Para la estadística inferencial se realizó un análisis de varianza de un factor para la comparación intergrupo. Resultados: Se incluyeron 64 ojos. En la comparación del grosor coroideo en el grupo control en el momento basal, a la hora y a las dos horas, no se observó una diferencia significativa (p = 0.29 y p = 0.13, respectivamente). Por otra parte, al realizar la comparación del grupo con nicotina, no observamos una diferencia estadísticamente significativa entre el grosor coroideo basal, a la hora y las dos horas (p = 0.57 y p = 1.43, respectivamente). Conclusión: En nuestro estudio no observamos que la goma de mascar con nicotina generara cambios transitorios en el grosor coroideo. Estos cambios podrían estar relacionados con el consumo crónico de nicotina y con el daño consiguiente generado por este consumo.
Purpose: To describe the primary cancer sites and clinical features of choroidal metastasis in Mexican patients. Methods: This was a retrospective, observational, and multi-center study. Data were recollected from 6 ophthalmological hospitals in Mexico from patients with choroidal metastasis diagnosed from 2000 to 2018. Results: Seventy-eight patients were studied: 43 were female and 35 were male. Mean age at presentation was 57.6 years. Overall, primary cancer sites were: 1) breast: 27 cases (34.6%); 2) lung: 19 cases (24.3%); 3) unknown: 8 cases (10.2%); 4) gastrointestinal: 7 cases (8.9%); 5) renal: 5 cases (6.4%); 6) testicular: 3 cases (3.8%); 7) ovary: 3 Cases (3.8%); 8) prostate: 2 cases (2.5%); 9) thyroid: 2 cases (2.5%); 10) carcinoid: 1 case (1.2%); and 11) multiple myeloma: 1 case (1.2%). Divided by gender, for women, the main three sites were: breast, unknown, and ovary. For men, the main three sites were: lung, gastrointestinal, and testicular. Oldest cases were breast cancer (87 and 85 years); youngest cases were testicular (23 and 25 years). Solitary lesions were observed in 56 cases (71.7%); multiple lesions were observed in 22 cases (28.2%). Forty-two cases had a white or yellowish color, while 6 cases presented an orange color. Conclusion: Primary cancer sites and clinical features of choroidal metastasis in Mexican patients show important differences from other populations previously studied, mainly the presence of a higher proportion of gastrointestinal and renal cancer, as well as higher incidence of ovarian and testicular cancer. These types of cancer, although not as common as breast or lung, need to be taken into account when studying Mexican patients living abroad.
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