Objective: To describe the clinical-laboratory profile of pediatric Guillain-Barre syndrome and delineate features associated with need of mechanical ventilation. Methods: In a prospective observational study at tertiary care hospital, clinical-laboratory assessment and nerve conduction studies were documented in consecutive children hospitalized with Guillain-Barre syndrome according to Brighton criteria. Clinical-laboratory features were compared between ventilated and nonventilated patients using univariate and multivariate analysis. Results: Forty-six children (27 boys) with a mean age of 69.1±35.2 months were enrolled. History of preceding infection was present in 47.8%, bulbar palsy in 43.5%, feeble voice in 41.3%, sensory involvement in 13%, and autonomic involvement in 39.5%. Tetraparesis was noted in 87% of cases. Hughes disability scale >3 was noted in 44 children at admission and 39 (84.7%) at discharge. The most common electrophysiological type was acute motor axonal neuropathy (46.5%) followed by acute motor sensory axonal neuropathy (39.5%), acute inflammatory demyelinating polyneuropathy (7%), and inexcitable nerves (7%). Nine (19.7%) children were ventilated, 3 (6.5%) died or were lost, and 43 were discharged. Factors associated with need of mechanical ventilation on univariate analysis were older age, hypertension, bulbar palsy, feeble voice, lower Medical Research Council (MRC) sum, raised total leucocyte count, and history of preceding infection. Logistic regression revealed older age, history of predisposing illness, lower MRC sum at presentation, and bulbar palsy as independent predictors of mechanical ventilation. Conclusions: The most common electrophysiological subtype in northern Indian children is acute motor axonal neuropathy. Older age, preceding infection, low MRC sum, and bulbar palsy are predictors of mechanical ventilation in pediatric Guillain-Barre syndrome.

Agricultural wastes disposal is of primary concern in today's world as they are rich in nutrient and their disposal without pretreatment can cause leaching in field, which can cause environment pollution. To overcome this problem, mushroom cultivation on these agricultural wastes is the most ecofriendly method to reduce the level of nutrients at acceptable range to be used as manure. Besides overcoming this problem defined combination of agricultural wastes also gives high yield of mushroom in a cost effective manner.

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Bitcoin Technology" Bitcoin is an innovative technology that offers several benefits, such as fast transaction speeds, low costs, and the elimination of the need for a third-party intermediary to process transactions. Unfortunately, BitCoin has faced resistance from regulators because the technology has been used for nefarious purposes, including online drug purchases and Ponzi schemes.This note provides a basic explanation of how BitCoin works and is currently regulated on federal and state levels. This note argues that BitCoin should not be forced into old regulatory frameworks that do not adequately balance security concerns with the benefits of BitCoin. BitCoin should not be regulated at the federal level. Instead, state regulations should focus on BitCoin providers that can unilaterally transfer or block transfers of BitCoin on behalf of users. State regulators should require such providers to register with their given states, maintain adequate books and records, implement advanced cyber security standards, conduct audits of their operations, and submit reports to state regulators. In crafting these regulations, regulators should keep in mind that vague or poorly drafted regulations will chill innovation.A Bitcoin would allow online payments to be sent directly from one party to another without going through a financial institution. Digital signatures provide part of the solution, but the main benefits are lost if a trusted third party is still required to prevent double-spending. We propose a solution to the double-spending problem using a peer-to-peer network.

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