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A skin lesion is a very severe problem, especially in coastal countries. Early detection by a highly reliable classification of skin lesion causes a great reduction in the mortality rate. Recognition of melanoma is a complicated issue due to the high degree of visual similarities between melanoma and non-melanoma lesions. Various studies are carried out to overcome this problem and to obtain accurate screening of skin lesion, where the most recent method for segmenting and classifying the lesion is based on a deep learning algorithm. In this paper, (GoogleNet) and (AlexNet) are employed with transfer learning and optimization gradient descent adaptive momentum learning rate (ADAM). The proposed method is applied on Archive International Skin Imaging Collaboration (ISIC) database to classify images into three main classes (benign, melanoma, seborrheic keratosis) under the two scenarios; segmented and non-segmented lesion images. The overall accuracy of the non-segmented classification database is 92.2% and 89.8% for the non-segmented dataset. Utilizing optimization algorithm (ADAM) leads to a significant improvement in the classification results when they are compared with previous studies.

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