Objective:The medial temporal lobe (MTL) encodes and recalls memories and can be a predominant site for interictal spikes (IS) in patients with focal epilepsy.It is unclear whether memory deficits are due to IS in the MTL producing a transient decline. Here, we investigated whether IS in the MTL subregions and lateral temporal cortex impact episodic memory encoding and recall.Methods: Seventy-eight participants undergoing presurgical evaluation for medically refractory focal epilepsy with depth electrodes placed in the temporal lobe participated in a verbal free recall task. IS were manually annotated during the pre-encoding, encoding, and recall epochs. We examined the effect of IS on word recall using mixed-effects logistic regression.
Highlights
Bilateral ictal onsets may lead to surgery failure in mesial temporal lobe epilepsy.
Bitemporal SEEG seizures were recorded despite of unilateral non-invasive tests.
Patients with non-lesional MTLE need bitemporal invasive evaluation before resection.
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