The use of blood liquid biopsy is increasingly being incorporated into the clinical setting of gastrointestinal cancers care. Clonal hematopoiesis (CH) occurs naturally as a result of the accumulation of somatic mutations and the clonal proliferation of hematopoietic stem cells with normal aging. The identification of CH-mutations has been described as a source of biological noise in blood liquid biopsy. Incorrect interpretation of CH events as cancer related can have a direct impact on cancer diagnosis and treatment. This review summarizes the current understanding of CH as a form of biological noise in blood liquid biopsy and the reported clinical significance of CH in patients with GI cancers.
Sudden cardiac death is a devastating and tragic event, especially in young, fit and healthy individuals with no prior symptoms or medical conditions. In these cases, death is caused mainly by a variety of inherited cardiac disorders, either with structural abnormalities or purely electrical heart diseases. Although in most cases conventional autopsy is able to establish the cause of death, there are cases when standard post-mortem examination fails to reveal the underlying cause of decease. Molecular autopsy (post-mortem genetic testing) is a requisite for the accurate diagnosis and also a standard of care along with detailed cardiologic assessment and informed genetic counselling of surviving relatives. This multidisciplinary approach could prevent future tragic events and facilitate development of preventive strategies.The goal of this review is to summarize the current state of knowledge regarding various genetic causes of sudden cardiac death emphasizing the requisite of post-mortem genetic testing for identifying surviving relatives at risk for future lethal events.
First four communities, representing the main research areas of ECOIND, contains articles authored by ECOIND researchers published in national and international journals, doctoral theses (abstract), conference papers, short description of the projects developed from 2006 till present, patents. The repository contains more than 800 documents, 850 author names, 1750 keywords. The research results presented within repository documents are related to development / implementation of the analytical control methods used to assess environmental pollution level (water, soil, sediments, air, waste products); ecotoxicological assessment studies for chemicals / polluted environmental samples regarding their biodegradability, acute and chronic toxicity on different aquatic organisms (fish, green algae, planktonic and benthic crustacean, rotifers, ciliates, plants and bacteria); modern procedures applied for advanced removal of dangerous compounds from water; technologies / biotechnologies applied for water treatment, clean technologies with low energy inputs, innovative biotechnologies presenting unconventional treatment processes; evaluation of the ecological risk determined on the environment (covering water, air, and soil components); industrial waste management-development of advanced methodologies for identification and assessment of the environmental risks caused by waste disposal; methodologies in the fields of quality management, environmental management, and health and occupational safety management.
Pterygium Colli or “palmate neck” is a congenital malformation that is most often part of a polimalformative syndrome. This deformity is a source of aesthetic and social embarrassment. Its correction is surgical. We present the case of a pterygium colli in a patient with Noonan syndrome. He had a significant excess of skin with posterior skin laxity, causing significant social discomfort and imposing a vicious attitude, the head bent forward. We performed a posterolateral resection of this excess by resecting two posterior triangular flaps with a resulting t-shaped scar. The results were satisfactory; the excess skin was almost completely resorbed with minimal scarring. However, this technique did not correct the low lateral hairline implantation, and there were still two lateral flaps for which the patient did not wish to have a repeat surgery.
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